... diseases like as cancer and AIDS. Apparently, superficial comparisons of DNAs slough over genetic details that result in major differences in the living animals. Some of the genetic differences between humans and chimps seem to belie that miniscule 1.5 % difference everyone bandies about. To illustrate, humans have only 46 chromosomes, while the great apes all have 48. The 1.5 % figure doesn't hint at this significant difference. Next, take a look at chromosome #9 in humans and the great apes. Chromosome bandings are different enough to raise further suspicions about the 1.5 % figure. (Gibbons, Ann; "Which of Our Genes Make Us Human?" Science, 281:1432, 1998.) Comments. It is easy to see how gross comparisons of DNA might miss important details. The popular "DNA-hybridization" method simply mixes together strands of DNA from the two species being compared. These are allowed to combine, and then they are heated to see how much temperature is required to force them apart. Chromosome numbers and bandings have little if any effect on these crude comparisons of the bare DNA strands that have been stripped from their genes and chromosomes. The significance of all this transcends the comparisons of humans and chimps. Modern taxonomy of all life forms depends increasingly upon DNA comparisons rather than upon morphology. If DNA comparisons can be as misleading as they are in humans and chimps, those textbook family trees that are supposed to tell us how life evolved may also be giving us an erroneous history of life. To underscore the problem ...

... OF BIRDS IN SPACE AND TIME BBD1 Discontinuous Populations of Birds BBD2 Uncolonized Areas: Unfilled Niches BBD3 Land Birds Observed Far at Sea BBD4 Late Survival of Moas and Passenger Pigeons BBD5 Distribution Curiosities BBE THE FOSSIL RECORD OF BIRDS BBE1 The Fossil Record of Birds and Associated Paradigms BBE2 Evidence against the Dinosaur Origin of Birds BBE3 Protoavis: A Pre-Archaeopteryx Bird? BBE4 Unresolved Nature of Archaeopteryx BBE5 The Apparent Absence of Transitional Forms of Feathers BBE6 Fossils of Ostrich Ancestors in the Northern Hemisphere BBE7 Controversial Feathers of the London Archaeopteryx Fossil BBE8 Giant Fossil Eggs BBF BODILY FUNCTIONS BBF1 The Avian Respiratory System: Unique, Complex, Sophisticated BBF2 Avian Bodily Functions: Some Oddities BBG GENETICS BBG1 Species mtDNA More Diverse Than Morphology BBG2 Discordance in the Date of Divergence of Modern Birds BBG3 Discordances between Phylogenies Established from Morphology and DNA Analysis BBG4 Dearth of Introns in Birds BBI INTERNAL STRUCTURES AND SYSTEMS BBI1 Avian Magnetoreceptors: Hard to Find BBI2 Curious Internal Structures BBO ORGANS BBO1 Complexity and Sophistication of Some Owl Ear-Brain, Sound-Localization Systems BBO2 Regeneration of Brain Neurons BBO3 Curiosities of Avian Brains BBO4 The Pecten: A Unique Structure in the Avian Eye BBO5 Curiosities of Avian Eyes BBO6 High Complexity and Sophistication of the Avian Eye BBO7 Remarkable Tongue Adaptations BBO8 The Loss and Reduction of Reproductive Organs BBT UNUSUAL TALENTS AND FACULTIES BBT1 Infrasound and Atmospheric Pressure-Change Detection BBT2 Utility of Ultraviolet Vision in Birds BBT3 Echolocation: Parallel Evolution in Birds BBT4 Navigational Feats during Migration BBT5 Homing: Release Experiments BBT6 Curious Migration Phenomena: Navigation Errors? BBT7 Complexity and Sophistication of Avian Navigation BBT8 Inheritance of Migration Data BBT9 The Existence of Avian ...

... influences," writes [R .] Greenspan, "but also the highly interconnected network of the nervous system sets up an additional layer of complexity between the gene and the realization of the phenotype." (Ref. 1) Many genes code for multiple variants of the same protein. And many proteins are modified by adding sugar molecules, which play a big role in determining where proteins go and what they do. What's more, different proteins can join together to carry out completely new functions. (Ref. 2) A group of French biologists, led by Francois Jacob and Jacques Monod showed that the gene's boundaries are fuzzier than had been thought and that genes are not restricted to chromosomes. Recently, biologists have found genes within genes, overlapping genes, and DNA sequences that specify one protein when read "forward" and another when read "in reverse." Muddling things further, the instructions encoded in the DNA do not always reach the ribosome as a literal translation. In a phenomenon known as RNA editing, an enzymatic highwayman intercepts the RNA message en route and alters it, so the resulting protein is not identical to that specified by the DNA. (Ref. 3) We can sum up by saying that a lot can happen to that information encoded in the genome before it is put to use. References Ref. 1. Anonymous; "The Flexible Genome," Nature, 411:xi, 2001. Ref. 2. Coghlan, Andy; "Privatising Your Proteins," New Scientist, p. 5, April 14 ...

... Science Frontiers ONLINE No. 139: Jan-Feb 2002 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects The Second Genetic Code And Apparently A Third Genes may or may not be switched on depending upon the addition of molecules called "methyl groups" to DNA. Now, a second kind of gene switch has been discovered on histones, a class of proteins. Figuring out when methylation of histones takes place has far-reaching implications; acting as a second genetic code, histone methylation may determine genetic traits such as the susceptibility to disease. (Martindale, Diane; "Genes Are Not Enough," Scientific American, 285:22, October 2001.) Comment. So, beyond the first genetic code (the DNA) and the second genetic code (the recognized methyl groups), we now have some proteins (the histones) getting in on the act. And the show ain't over yet! From Science Frontiers #139, Jan-Feb 2002 . 2001 William R. Corliss Other Sites of Interest SIS . Catastrophism, archaeoastronomy, ancient history, mythology and astronomy. Lobster . The journal of intelligence and political conspiracy (CIA, FBI, JFK, MI5, NSA, etc) Homeworking.com . Free resource for people thinking about working at home. ABC dating and personals . For people looking for relationships. Place your ad free. ...

... Science Frontiers ONLINE No. 10: Spring 1980 Other pages Home Page Science Frontiers Online All Issues Last Issue Next Issue Sourcebook Project Sourcebook Subjects Contents Archaeology A Sun-and-spiral Clock Astronomy Io's Electrical Volcanos Double Hubble: Age in Trouble Biology Chinese Hunt Red-haired Bigfoot The Universal Urge to Join Up Why Birds Are Pretty Dynamic DNA Geology Cosmic Death Waves The Nuclear Threat: Bad Dates Geophysics Homing in on the Hum Ice-flake Fall Long-delayed Radio Echoes Luminous Ripples Move Through the Night Sky Psychology Bend Interferometers Not Spoons ...

... Science Frontiers ONLINE No. 34: Jul-Aug 1984 Other pages Home Page Science Frontiers Online All Issues Last Issue Next Issue Sourcebook Project Sourcebook Subjects Contents Archaeology Ancient Wisconsin Astronomers The Guadeloupe Skeleton Revisited Pouring A Pyramid A Demurrer From the Epigraphic Society Ancient Old-world Lamps Turn Up in New England Astronomy Does String Hold the Universe Together? The Big Bang As An Illusion A Gathering of Quasars Biology Our Aquatic Phase! Dna even more promiscuous A Note on Perfect Pitch Sunspots and Disease Are Parasites Really the Masters? Geology The Carbon Problem Behind Magnetic Flip-flops Geophysics Aggressive Ball Lightning Low-level Aurora? The Marfa Lights Psychology The Mind's Control of Bodily Processes Hostage Hallucinations Techno-jinx Unclassified Strange Object in the Sky ...

... Science Frontiers ONLINE No. 91: Jan-Feb 1994 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Dna Undermines Key Paradigms Lately, the Wall Street Journal has expanded its coverage from stocks and bonds to the Marfa lights and other scientific anomalies. Now, it is challenging archeological sacred cows using mitochondrial DNA. Quite a switch from pork futures! Of course, the WSJ is not a recognized scientific source, but its reporter did get his information directly from D.C . Wallace, a well-known professor of genetics and molecular medicine at Emory University and a champion of the African Eve theory. Surely an unusual illustration for the archeology section, but the DNA in these mitochondria may upset long-held theories of human migration. Anyway, Wallace has been studying mitochondria, those little energizers in human and animal cells. Strangely, mitochondria have their own DNA, which is separate and distinct from the nuclear DNA that directs other biological processes. Mitochondrial DNA has had its own history of evolution and is different for various human populations. Wallace has used this fact to trace the origins of American Indians by comparing their mitochondrial DNA with that from Asians, Africans, etc. His conclusions are controversial to say the least. The Amerinds, who comprise most of the Native Americans, arrived in a single migratory wave 20,000-40,000 years ago -- not merely 12,000 years ago! Native Siberians lack a peculiar mutation of mitochondrial DNA that appeared in the Amerinds 6,000-10,000 years ago ...

... Science Frontiers ONLINE No. 94: Jul-Aug 1994 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Our genes aren't us!Almost without exception, biology textbooks, scientific papers, popular articles, and TV documentaries convey the impression that an organism's genes completely specify the living animal or plant. In most people's minds, the strands of DNA are analogous to computer codes that control the manufacture and disposition of proteins. Perhaps our current fascination with computers has fostered this narrow view of heredity. Do our genes really contain all the information necessary for constructing human bodies? In the April 1994 issue of Discover, J. Cohen and I. Stewart endeavor to set us straight. The arguments against the "genes-are-everything" paradigm are long and complex, but Cohen and Stewart also provide some simple, possibly simplistic observations supporting a much broader view of genetics. Mammalian DNA contains fewer bases than amphibian DNA, even though mammals are considered more complex and "advanced." The implication is that "DNA-as-a -message" must be a flawed metaphor. Wings have been invented at least four times by divergent classes (pterosaurs, insects, birds, bats); and it is very unlikely that there is a common DNA sequence that specifies how to manufacture a wing. The connections between the nerve cells comprising the human brain represent much more information than can possibly be encoded in human DNA. A caterpillar has the same DNA as the butterfly it eventually becomes. Ergo, something ...

... Science Frontiers ONLINE No. 93: May-Jun 1994 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Molecular clock places humans in new world 22,000-29,000 bp This is welcome news for anomalists who have been searching for a way to demolish the 12,000-BP (years Before Present) barrier erected across the Bering Land Bridge by the archeological establishment. But don't uncork the champagne yet, because molecular clocks are not like Big Ben. Here's what has happened: A. Torroni and some colleagues at Emory University have analyzed the mitochondrial DNA (mtDNA) of members of seven linguistically related tribes in Central America called the "Chibcha speakers." Assuming that the homogeneous group separated from the other Amerind tribes 8,000-10,000 years ago, the Emory group found that their mtDNA had mutated at the rate of 2.3 -2 .9 % per million years. (Note: this works out to 0.0022-0 .0029% per thousand years -- a very small amount to measure accurately!) Next Torroni et al measured the mtDNA of 18 other tribes throughout the Americas and, using the mutation rate just mentioned, computed how long ago these peoples had diverged from a common ancestor. The result: 22,000-29,000 years ago. The Emory study was published in the February 1, 1994, issue of the Proceedings of the National Academy of Sciences . All this is very well, but suppose that the tribes had ...

... as well as we thought it did. In particular, the major phylogeny of the animal kingdom as estimated from adult characters doesn't fir very well with that estimated from larvae. Such a discrepancy for different stages has occasionally been reported within families of insects, and it has an apparent resemblance to the discordance occasionally found between phylogenies inferred from morphological and molecular characters. In such cases, the usual conclusion (I ignore data chauvinists) is that we should somehow use all the available information to infer the correct phylogeny. After all, there was just one real phylogeny that occurred in the past, and we want to find it as closely as we can." Comment inserted by the compiler. Van Valen is saying that three evolutionary Trees of Life can be drawn from adult morphology, DNA structure, and larval morphology, and that they may not look the same. Caterpillars may yield a family tree different from that inferred from the butterflies. Which is correct, or are they all correct? Back to the review. Waxing heretical, Williamson points out that an organism may have more than one phylogeny ! Larvae may have ancestries different from the adults. How heretical can one get? But in the ocean, spermatozoa often cannot find an egg of the correct species. They may then fertilize eggs of a distantly related species. In such "wide hybrids," the larvae may resemble one parent and the adults the other. There is much more. The gist of it all is that evolution has been much more than random mutation and natural selection. Hybridization and outright mergers ...

... World. What besides a chemical soup might have existed before "life-as-we-know-it" arrived upon the scene? A science fiction writer like H.P . Lovecraft could certainly come up with an ominous entity based upon RNA alone. Be that as it may, a book is now on the market bearing the title The RNA World (R .F . Gesteland and J.F . Atkins, eds., Cold Spring Harbor Laboratory Press, 1993) Nature reviewed the book in its January 20 issue. In addition, the RNA World was discussed recently in Science. We now extract one nugget from each of these two sources. From Nature's review. Humans are more primitive than microorganisms in the sense that we still retain cumbersome introns (nonsense DNA) in our genes, while lowly microorganisms have been able to eliminate them. From Science. No one seems to have a clue about where RNA came from. C. de Duve ventured that: ". .. the emergence of RNA depended on robust chemical reactions -- it is wrong to imagine that some fantastic single accidental event supported the development of the RNA World." In connection with the generally accepted idea that the evolution of RNA must have taken hundreds of millions of years: ". .. de Duve suggested that, on the contrary, for such a complex chemical process to succeed it must have been relatively fast in order to avoid decay and loss of information." (Brenner, Sydney; "The Ancient Molecule," Nature, 367:228, ...

... Science Frontiers ONLINE No. 109: Jan-Feb 1997 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Biology Heavy Paleontology vs. DNA. The so-called Cambrian Explosion has been the subject of two SF items (SF#60/187 and SF#85/ 187). A paleontological fact of life is that all known body plans (phyla) seem to have evolved suddenly -- within a few million years -- after the onset of the Cambrian period some 545 million years ago. Evolutionists are understandably uncomfortable with such a high rate of evolutionary innovation. Nothing like the Cambrian Explosion appears in the hundreds of millions of years of geological strata that followed. So rapid was speciation during the Cambrian Explosion that doubt is cast upon the accepted mechanisms of evolution: slow, stepwise accumulation of mutations plus natural selection. (Refs. 1 and 2) But G.A . Wray and colleagues seem to have rescued Darwinism. They have analyzed the DNA sequences of seven genes found in living animals. Assuming that these genes mutate at constant rates and working backwards in time, they calculate that animal diversification (i .e ., when chordates diverged from invertebrates) actually began about 1 billion years ago, rather than about 545 million years ago. This expansion of the time frame gives accepted evolutionary processes much more time to innovate and create all those new body plans. The evolutionists are pleased. The paleontologists, however, are in a quandry. They see nothing -- or very little -- in the Precambrian fossil ...

... Science Frontiers ONLINE No. 111: May-Jun 1997 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Chromosome Choreography Every biology student has seen sketches of the "dance of the chromosomes" that is performed when eukaryote (nucleuscontaining) cells divide. Because chromosomes are composed of genes and their DNA -- the information carriers of inheritance -- it reasonable to suppose that they are the "dance-masters." This expectation is enhanced if one holds that the genes are "selfish;" that is, they have their own evolutionary agendas, and all life forms exist only to execute their "will." But cell division would not occur at all without the action of the cell's bipolar spindle. This spindle is composed of microtubules -- rods of the protein "tubulin." Somehow , when cells are about to divide, they synthesize these microtubules, which then seem to organize themselves into orderly arrays (the bipolar spindles). Then, the microtubules sort out and separate the two sets of chromosomes required for the two new cells. So, far, our description conforms to what biologists have known and accepted for decades; but there is something more mysterious going on. In 1996, researchers discovered that they can actually substitute DNAcovered beads for the chromosomes, and the microtubules will still go through the motions of sorting and separating the chromosome-less strands. Actually, the microtubules will perform their act even without the DNA-covered beads. In a sense, the bipolar spindle is a puppetmaster, and the ...

... 9,300 years old." (Ref. 2) Actually, the skeleton may well be that of a "pioneer" but one who came from the direction of the setting sun instead of the rising sun. Of course, it is perfectly all right for Asians to have crossed the Bering Strait into North America over 9,000 years ago, but a Caucasian raises scientific and emotional problems. "If Kennewick Man were actually Caucasian, it would be a startling discovery. So far, all of the oldest North American skeletons have been of Asian descent, although features on a few skulls have been controversially interpreted as Caucasoid. Another possibility is that the first Americans -- and their Asian ancestors -- had features that were Caucasoid. The real test of these theories would be DNA, which can pinpoint which modern populations are most closely related to the skeleton and so help identify the ancestors of early Americans and perhaps give clues to their migration patterns." (Ref. 3) But science may not get the opportunity to make the desired DNA tests. The local Umatilla Indians insist that the bones of Kennewick Man be surrendered to them for immediate reburial, as stipulated by the North American Graves Protection Act of 1990. But if the bones are truly those of a Caucasian, does the Act apply? And when does the scientific value of a skeleton outweigh native tradition? Ironically, the Umatilla Indians scoff at the idea of Asian diffusion across the Bering Strait. They claim that they have always lived in the Pacific Northwest! (Ref. 4) Comment. Perhaps ...

... Science Frontiers ONLINE No. 116: Mar-Apr 1998 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Eco-Darwinism: Diffuse Individuals Epigenetic phenomena -- those phenomena beyond the pale of DNA -- are seen in "diffuse individuals" such as fungi, where it is difficult to separate individual units of life. To illustrate, some fungi may be 1,000 years old and extend for 35 acres (15 hectares) and yet possess a single, still unmodified genome. In his review of A. Rayner's new book Degrees of Freedom: Living in Dynamic Boundaries , T. Wakeford writes: "So, like the World Wide Web, a fungal network is decentralized. There is no central region capable of exerting control over the rest of the network. Rayner's own work suggests that the growth patterns of fungal filaments are forged as much by the environment that they encounter as by their genes. He believes that epigenetics, the process whereby opportunities in an organism's surroundings dictate which genes are expressed, is the norm in microorganisms. Genetic determinism is thus turned on its head." (Wakeford, Tom; "We Are the Fungus," New Scientist, p. 49, May 10, 1997.) Comment. Looking at the above situation from an information viewpoint, as one must these days, it seems that the environment can somehow "interpret" genes as the situation demands. In other words, genes are not "single-message" information carriers, but can be " ...

... Advancement of Science (AAAS) in Philadelphia, anthropological heresies ran rampant. T. Dillehay, who directed the Monte Verde work, declared that there were 15-20 other South American sites older than 11,500 years. Monte Verde itself may have been founded 33,000 years ago. D. Stanford, Smithsonian curator of archeology, opined that there were probably several waves of prehistoric immigration into the Americas across the Arctic, the Pacific Ocean (! ), and possibly even the Atlantic (! !) . [This is heresy no longer.] Supporting early Atlantic crossings are several dozen artifacts found in the eastern U.S . that closely resemble some found in France and Iberia. Stanford said, "We don't know yet what that means." Studies of DNA diversity among New World Indian populations find such large differences that at least 30,000 years would have been needed for these differences to develop. (Assuming, of course, a relatively homogeneous group of initial colonists.) Linguist, J. Nichols, from Berkeley, sees a similar diversity in the languages of New World peoples. Some 140 language families -- half the world total -- are found in the Americas. Nichols estimates that it would have taken a minimum of 40,000 years for such diversification. (Again assuming initial homogeneity.) Nichols also pointed out strong similarities in languages all around the Pacific Rim, from New Guinea north to Siberia, around Alaska, and down the west coast of the Americas. The implication is that many of these peoples derived from ...

... Science Frontiers ONLINE No. 158: Mar - Apr 2005 Other pages Home Page Science Frontiers Online All Issues Last Issue Next Issue Sourcebook Project Sourcebook Subjects Contents Archaeology Untranslatable Mohenjo-Daro Script? A very Early Compound Machine Khufu's Secret Burial Chamber: A Phony Discovery? Astronomy Allez Allez Old Galaxies in a Young Universe Biology Do Dolphins Sense the Coriolis Force? Disappearing Animals Wayward DNA: Does it Affect the Shapes of Family Trees? Geology Bermuda Triangles in the Desert! Plate-techtonics 'theory' is slowly and inevitably Dyning Geophysics Hum Update Psychology Motherese: A precursor of Human Language? Unclassified Multimedia Communications in the Cosmos Computer Bacteria ...

... Science Frontiers ONLINE No. 11: Summer 1980 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Hierarchies Of Evolution All organisms from man to mouse to amoeba are merely DNA's way of manufacturing still more DNA -- so goes the modern ramification of molecular biology and the Genetic Code. In other words, DNA and genes are selfish, and ultimate parasites, directing the evolution of life only to maximize the production of DNA. This theme is not the subject of this paper by Doolittle and Sapienza. Rather, they wonder about those nonsense DNA sequences that do not code for protein. The presence of these "useless" bits of genetic material is often explained in terms of gene "expression." Emphasis is always on maximizing the "fitness" of the organism (phenotype). Perhaps this seemingly excess genetic material actually maximizes the fitness (survivability) of the DNA itself. Evolution thus occurs at DNA and gene (genome) levels, despite what transpires at the organism (phenotype) level. (Doolittle, W. Ford, and Sapienza, Carmen; "Selfish Genes, the Phenotype Paradigm and Genome Evolution," Nature, 284:601, 1980.) Comment. We know that mitochondria and chloroplasts have their own genetic material; evolution may be occurring at this level, too, independent of pressures for change on the organisms. Waxing speculative, may there not be other hierarchies where systems are trying to maximize their own survivability, even at molecular, atomic, and subatomic levels? Don't laugh! ...

... Science Frontiers ONLINE No. 22: Jul-Aug 1982 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects The Nomads Within Us It was originally believed that human chromosomes were fixed at conception and all subsequent organic development proceeded from the instructions encoded on them. Biologists have recently discovered that genes grasshopper about, constantly modifying genetic instructions -- at least that's the current thinking. Additional modification of genetic instructions seems to be accomplished by entities called "nomads" or "mobile dispersed genetic elements." One type of nomad is a simple ring of DNA called a plasmid. Plasmids seem to be identical to a kind of virus called a retrovirus, which can penetrate into cells and tamper with gene expression; that is, the way genetic instructions are interpreted. Plasmids have been discovered in maize, fruit flies, bacteria, and, now, humans -- and healthy people at that. No one is quite sure what these plasmids do. Even though they look like retroviruses, they may not be associated with illness, but rather help organisms adapt to changing environments. But no one really knows. (Anonymous; "Human Wandering Genes Can Live on Their Own," New Scientist, 94:18, 1982.) Comment. So, the human body is not only beset by new genetic instructions and the static introduced by invading viruses and other disease agents, but it has an indigenous population of nomads continually fiddling with our cells' genetic instructions. Our bodies seem more like Grand Central Station with trains loaded with new biological ...

... Science Frontiers ONLINE No. 25: Jan-Feb 1983 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Promiscuous Dna The cells of plants (photosynthetic eukaryotes) are genetically the most complex that biologists have discovered. Each cell has three genetic systems: its own, that of the chloroplasts; and that of the mitochondria. It is supposed that the chloroplasts and mitochondria were once free-living cells that linked up with the embryonic plant cell to form a symbiotic partnership, with the host "plant" cell being the dominant member. Up until now, the three genetic systems were thought to be discrete, each going down its own pathway. But chloroplasts genes have now been found inside plant mitochondria, overturning conventional wisdom. To sum it all up, DNA seems promiscuous -- no respecter of privacy and breaking down all isolating genetic barriers. This discovery at once raises a dozen questions. For example, are mitochondria genes in chloroplast cells? How far does this promiscuity go? Can the same thing happen in higher organisms; say, with humans and symbiotic microorganisms or even not-so-symbiotic disease organisms? Is there no stopping this DNA? (Ellis, John; "Promiscuous DNA -- Chloroplast Genes inside Plant Mitochondria," Nature, 299:678, 1982.) From Science Frontiers #25, JAN-FEB 1983 . 1983-2000 William R. Corliss ...

... Science Frontiers ONLINE No. 36: Nov-Dec 1984 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Evolution Of Man And Malaria Malarial parasites are customarily classified according to the species infected and then further subdivided by morphology and biological characteristics. The two assumptions implicit in this classification procedure, which is supposed to mirror actual historical evolution, are: Malarial parasites evolved in parallel with their hosts; and Morphology is a measure of evolutionary relatedness. With modern biochemical techniques it is possible to test these assumptions by comparing the DNA structures of the different malarial parasites. P. falcipa rum, the parasite transmitting the most deadly human malaria, turns out to be more closely related to rodent and avian malaria than the other primate malarias. Therefore, assumption #1 above is in correct in this view. Assumption #2 is also wrong because some species of malaria parasites which are very similar morphologically are quite different DNAwise. (McCutchan, Thomas F., et al; "Evolutionary Relatedness of Plasmodium Species as Determined by the Structure of DNA," Science, 225:808, 1984.) Comment. The article does not draw attention to still another assumption; namely, that similarities are measures of evolutionary relatedness. If this as sumption isn't correct, evolutionary family trees based on bodily structure, which means most of the family trees in the textbooks, may not truly reflect what really happened in the development of life. Further, if malarial parasites did evolve along with their hosts, hu man evolution seems farther removed from the evolution ...

... Its Time," Nature, 309:400, 1984.) Comment. This is an appropriate time to suggest that "psychoevolution" may be physiologically possible. If the brain can fight disease and even control cell growth, why not a role for the mind in stimulating the development of new spe cies, perhaps in response to extreme environmental pressures, and perhaps not on the conscious level? The body's sensory system would detect great external stresses, the brain would process the information, and direct some astute genetic shuffling. The genetic inheritance of an organism is not sacrosanct. Radiation, chemicals, and various others mutagens are recognized. There seems to be no a priori reason why the brainbody combination cannot generate mutagens -- possibly not randomly but intelligently! (We ignore here selfish DNA and Sheldrake's morphogenic fields.) Does this mean that if we wish to mutate, we can? Well, it's probably not as simple as wishing warts away, but Maddox's editorial underscores the complexity and subtlety of the brain-body combination. From Science Frontiers #35, SEP-OCT 1984 . 1984-2000 William R. Corliss ...

... Science Frontiers ONLINE No. 50: Mar-Apr 1987 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects How Cancers Fight Chemotherapy How do cancer cells develop resistance to lethal chemicals? The clues seem to reside in extrachromosomal DNA that carries drug-resistance-conferring genes from one cancer cell to another. Cancer cells dying from chemotherapy may, for example, cast off extrachromosomal DNA that carries information on how to combat the chemicals. Other factors may also be at work, but basically we have only suspicions. (Silberner, Joanne; "Resisting Cancer Chemotherapy," Science News, 131:12, 1987.) Comment. Insects and other organisms also acquire resistance to chemical poisons. Does extrachromosomal DNA play roles in these instances, too? Can Information coded in extrachromosomal DNA be passed from one species to another, say, via insect bites? From Science Frontiers #50, MAR-APR 1987 . 1987-2000 William R. Corliss ...

... Science Frontiers ONLINE No. 41: Sep-Oct 1985 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Genetic Garrulousness It is tempting to predict that those cells with the most genetic material will belong to the most advanced organisms. One would, for example, expect to find more DNA or nucleotide pairs in human cells than the cells of bacteria or plants. In the case of the bacteria, this expectation is realized. Some plants, however, have one hundred times more DNA per cell than humans. Some fish and salamanders do, too. One reason why there is no simple relationship between a cell's genetic complement and the organism's complexity is that a lot of genetic material is apparently useless, with no known functions. Human genes, by way of illustration, possess about 300,000 copies of a short sequence called Alu. The Alu sequences seem to be simply dead weight -- functionless -- yet continuously reproduced along with useful sequences. One purposeless mouse gene sequence is repeated a million times in each cell. (Stebbins, G. Ledyard, and Ayala, Francisco J.; "The Evolution of Darwinism," Scientific American, 253:72, July 1985.) Comment. Why so much redundance? Or is there some purpose for this excess genetic material that we haven't yet descried? The "useless" sequences may merely be left over from ancient gene shufflings; or they may be awaiting future calls to action. The above tidbits come from a long review article that is ...

... own, how do the prions multiply? Recent laboratory work suggests that the prions subvert a gene that normally dwells in the brain. With the help of this gene, an endless stream of prions emerges, and the animal is sick. In hamsters, which are employed in laboratory research on scrapie, a gene demarcated PrP has been implicated in scrapie. PrP is present in both healthy and infected hamster brains, but no one knows what its normal function is, if indeed it has one. (Anonymous; "Prion Gene," Scientific American, 253:60, July 1985.) Comment. One can make an immediate connection between the traitorous PrP genes in the hamster brains and the excess genetic material in humans and all life forms. Biologists commonly call excess genetic material "nonsense DNA" which only means that they haven't devined its purpose. But, as already sugested, these unused blueprints may have had some past purpose or will be called into action in the future. The purpose may be insidious, as in the case of scrapie, or vital to the organism's survival in some unrecognized biological Armageddons. From Science Frontiers #41, SEP-OCT 1985 . 1985-2000 William R. Corliss ...