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... Science Frontiers ONLINE No. 64: Jul-Aug 1989 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Directed Mutation Dear reader, things have a way of working out serially. For several months, we have had in our possession a paper from Nature, by J. Cairns, of Harvard, plus some passionate correspondence stimulated by the paper. Now that the circle-forming sheep have provided a good introduction, we will jump into the fray, too. Basically Cairns (in Nature) and B. H. Hall (in Genetics ) say that organisms can respond to environmental stresses by reorganizing their genes in a purposeful way. Such "directed mutation" shifts the course of evolution in a nonrandom way. Such a conclusion was like ... a red flag in front of the evolutionists. R. May, at the University of Oxford, complained, "The work is so flawed, I am reluctant to comment." On the other side, a University of Maryland geneticust, S. Benson, comments, "Many people have had such observations, but they have problems getting them published." Our template in this discussion is an article by A.S . Moffat in American Scientist. She says, "The stakes in this dispute are high, indeed. If directed mutations are real, the explanations of evolutionary biology that depend on random events must be thrown out. This would have broad implications. For example, directed mutation would shatter the belief that organisms are related to some ancestor if they share traits. Instead ...
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... Science Frontiers ONLINE No. 72: Nov-Dec 1990 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Hypermutation rather than directed mutation?The year 1988 saw a flurry of excitement over the purported discovery of "directed mutation" in the laboratory; that is, mutations of organisms that seemed goal-directed rather than random and independent of environmental pressures. The concept of directed mutation is counter to prevailing biological dogma, and, naturally, this research bore severe scrutiny. Objections and arguments against directed mutation arose, but the original research was never shown to be faulty. New experiments along this line, by B. Hall at the University of Rochester, have supported the original Harvard work and refuted some of the objections that had been leveled. ... with a special strain of Escherichia coli , Hall starved the bacteria of a certain amino acid, (tryptophan) that they usually got from the environment and could not synthesize. In the days that followed, many of the bacteria mutated so that they could synthesize their own tryptophan. Hall concluded: "Mutations that occur more when they're useful than when they're not: That I can document any day, every day, in the laboratory." Rather than assign any "conscious" goal-seeking attributes to the bacteria, Hall prefers to think that the environmental stress induced a state of "hypermutation." In this state all sorts of mu-tations occurred in abundance. Only those that synthesized tryptophan survived the starvation program; even potentially favorable mutations died quickly. ( ...
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... , environment-independent generation of genetic mutations; and, second, the subsequent fixation of those mutations that are favored by prevailing conditions. In other works, the genetic mutations cannot be influenced by external events and conditions. But in recent experiments with bacteria (E . coli), J. Cairns et al, at the Harvard School of Public Health, find they actually do produce mutations in direct response to changes in their environment. The adjective "purposeful" has even been applied to the action of these bacteria! Can anything be more heretical? "One of the experiments involves taking colonies of E. coli that are incapable of metabolizing lactose and exposing them to the sugar. If the lactose-utilizing mutants simply arise spontaneously in the population and are then favored by prevailing conditions, ... Science Frontiers ONLINE No. 60: Nov-Dec 1988 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Purposeful evolution?One seemingly unassailable dogma of evolutionary biology insists that natural selection involves, first, the continuous, random, environment-independent generation of genetic mutations; and, second, the subsequent fixation of those mutations that are favored by prevailing conditions. In other works, the genetic mutations cannot be influenced by external events and conditions. But in recent experiments with bacteria (E . coli), J. Cairns et al, at the Harvard School of Public Health, find they actually do produce mutations in direct response to changes in their environment. The adjective "purposeful" has even been applied to the action of these bacteria! ...
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... Science Frontiers ONLINE No. 96: Nov-Dec 1994 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects "ADAPTIVE" MUTATION Six years ago, J. Cairns performed experiments with bacteria that implied that said bacteria could "direct" their own mutations so that they could cope more speedily with sudden environmental trauma. (SF#64) In Cairns' experiments, bacteria unable to digest lactose were presented with an all-lactose diet. They quickly acquired the mutations needed to digest the only food available. They did not have to wait for random mutations to accidentally hit upon the correct genome changes. A firestorm spread across the scientific community, even though other researchers saw similar effects. It was traumatic! One of science's foundation stones ... Science Frontiers ONLINE No. 96: Nov-Dec 1994 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects "ADAPTIVE" MUTATION Six years ago, J. Cairns performed experiments with bacteria that implied that said bacteria could "direct" their own mutations so that they could cope more speedily with sudden environmental trauma. (SF#64) In Cairns' experiments, bacteria unable to digest lactose were presented with an all-lactose diet. They quickly acquired the mutations needed to digest the only food available. They did not have to wait for random mutations to accidentally hit upon the correct genome changes. A firestorm spread across the scientific community, even though other researchers saw similar effects. It was traumatic! One of science's foundation stones ...
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... Science Frontiers ONLINE No. 75: May-Jun 1991 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Can organisms direct their evolution?" In 1988. Harvard molecular biologist John Cairns committed an act of scientific heresy. He proposed in a Nature article that bacteria living in an unfavorable environment are able to choose which mutations to produce to adapt to the stressful situation. Cairns made his directed-mutation hypothesis in response to an unusual finding -- data that strongly hinted bacterial mutations might occur more often when beneficial." The above quotation is the lead paragraph in a long BioScience article that details the consternation Cairns' results have created in the biological community. The problem that biology-as-a -discipline has is that it has deified ... paradigm: neo-Darwinism. Now, neo-Darwinism is supported by many experiments showing that some mutations are indeed random. Consequently, as M. Gillis re-marks in her BioScience article, the biological community 'got locked into its belief that an organism cannot control its own mutation.' Furthermore, Cairns' claims recall the long battle with Lamarckism, a subject that biology has closed-the-book-on. In a nutshell, Lamarckism has been interred since the 1950s, and 'Nobody wants to give the appearance of straying from the neoDarwinism fold.' Gillis goes on to review some recent experiments supporting those of Cairns. But, impressive though these may be, there have been neo-Darwinian explanations for some of the results. Even so, more and more ...
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... that something must have occurred about that time to greatly favor the survival of people carrying the mutation." What biological catastrophe decimated Europe 700 years ago? The Black Death. One-quarter to one-third of the Europeans succumbed between 1347 and 1350. The Black Death strongly modified the European gene pool, increasing the frequency of CCR5-delta 32. This mutation may not have had any direct effect on the plague itself. It may just be a quirk of fate that the survivors of the Black Death had a higher frequency of the CCR5-delta 32 mutation, and it is doubly quirky that the mutation confers a resistance to AIDS, which is a recent human affliction. About 10% of whites of European origin now carry the CCR5-delta 32 mutation. The incidence is ... pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects The black death and ccr5-delta 32 Plagues are not all bad, and the Black Death (bubonic plague) that swept into Europe from Asia in 1346 was no exception. It is now common knowledge that bacteria, insects, plants, and even humans can build up resistances to poisons, diseases, and antibiotics. Mutations are always occurring; some good, some neutral, some bad. It has been found that a human mutation designated CCR5-delta 32 confers immunity to AIDS if inherited from both parents. People carrying the CCR5-delta 32 mutation lack the receptors to which the AIDS virus must attach itself if it is to infect the person. What has all this to do with the Black Death? ...
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... Science Frontiers ONLINE No. 130: JUL-AUG 2000 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Has Human Evolution Been Directed by Bacteria?With considerable fanfare, a multinational team of scientists has announced that the mtDNA (mitochondrial DNA) "squeezed" from a 29,000-year-old Neanderthal skeleton found in the northern Caucasus differs by 3.48% from the mtDNA of a 40,000-year-old Neanderthal skeleton from (fittingly) Germany's Neander Valley. Furthermore, both mtDNA samples differ from that of modern humans by a substantial 7%. These two innocent-appearing, widely publicized numbers have far-reaching implications: Modern humans and Neanderthals are only very distantly related, and they certainly never ... observations and comments; only one of which is mentioned in the references given below. F.H . Smith, an anthropologist from Northern Illinois University and a supporter of the multiregional theory, opines that 30,000-40,000 years ago the mtDNA of the early humans, who were mixing it up with the Neanderthals, was certainly very different from what it is today. Since mtDNA mutates rapidly, way back then human mtDNA might have been much more like that of the Neanderthals. (Ovchinnikov, Igor V., et al; "Molecular Analysis of Neanderthal DNA from the Northern Caucasus," Nature, 404:490, 2000. Bower, B.; "Salvaged DNA adds to Neandertals' Mystique," Science News, 157:213, 2000. Donn, ...
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... Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Dna Undermines Key Paradigms Lately, the Wall Street Journal has expanded its coverage from stocks and bonds to the Marfa lights and other scientific anomalies. Now, it is challenging archeological sacred cows using mitochondrial DNA. Quite a switch from pork futures! Of course, the WSJ is not a recognized scientific source, but its reporter did get his information directly from D.C . Wallace, a well-known professor of genetics and molecular medicine at Emory University and a champion of the African Eve theory. Surely an unusual illustration for the archeology section, but the DNA in these mitochondria may upset long-held theories of human migration. Anyway, Wallace has been studying mitochondria, those little energizers in human and animal cells. Strangely, mitochondria ... has used this fact to trace the origins of American Indians by comparing their mitochondrial DNA with that from Asians, Africans, etc. His conclusions are controversial to say the least. The Amerinds, who comprise most of the Native Americans, arrived in a single migratory wave 20,000-40,000 years ago -- not merely 12,000 years ago! Native Siberians lack a peculiar mutation of mitochondrial DNA that appeared in the Amerinds 6,000-10,000 years ago, casting doubt on the Siberian land bridge theory. Instead, this particular mutation is found in Southeast Asia, Melanesia, and Polynesia. The Navajos, Apaches, and other so-called Na-Dene peoples entered North America a mere 5,000-10,000 years ago. The article ...
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... , rather than about 545 million years ago. This expansion of the time frame gives accepted evolutionary processes much more time to innovate and create all those new body plans. The evolutionists are pleased. The paleontologists, however, are in a quandry. They see nothing -- or very little -- in the Precambrian fossil record that substantiates the claim of Wray at al. Thus, molecular biology directly contradicts the findings of paleontology. Not to worry say supporters of the new and much more comfortable scenario: The Precambrian animals were so soft and "squishy" that they did not fossilize well. (Ref. 3) Comment. The molecular biologists are a bit arrogant in their assertions. They seem to assume that because they can quantify molecular divergences; that is, fill their journal contributions ... a few million years -- after the onset of the Cambrian period some 545 million years ago. Evolutionists are understandably uncomfortable with such a high rate of evolutionary innovation. Nothing like the Cambrian Explosion appears in the hundreds of millions of years of geological strata that followed. So rapid was speciation during the Cambrian Explosion that doubt is cast upon the accepted mechanisms of evolution: slow, stepwise accumulation of mutations plus natural selection. (Refs. 1 and 2) But G.A . Wray and colleagues seem to have rescued Darwinism. They have analyzed the DNA sequences of seven genes found in living animals. Assuming that these genes mutate at constant rates and working backwards in time, they calculate that animal diversification (i .e ., when chordates diverged from invertebrates) actually began about 1 ...
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... Science Frontiers ONLINE No. 64: Jul-Aug 1989 Other pages Home Page Science Frontiers Online All Issues Last Issue Next Issue Sourcebook Project Sourcebook Subjects Contents Archaeology Bimini archeological anomalies Who left these artifacts in burrows cave? Astronomy Halley: a young, combusting, alien interloper Bright flash on the moon is 1985 Biology Poets at sea: or why do whales rhyme? Sheep circles! Directed mutation Geology The earth as a cold fusion reactor Libyan desert glass Geophysics The zeitoun apparitions Ball lightning in yorkshire Psychology Dream esp and geomagnetic activity Physics Cold fusion update General The 1977 "wow" signal ...
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... ". .. one of the most remarkable morphological features ever found in spiders (immense elongations of the tarsal claws)." These claws, just visible on the two lowermost pairs of legs in the sketch, are employed to skewer passing insects in flight: "The spider is strictly nocturnal, spending most of the activity-period hanging upside down from silk threads. Small insects are snagged directly from the air using a single long claw. For larger insects the spider uses both long claws on legs I, or sometimes all the long claws." (Gillespie, Rosemary G.; "Impaled Prey," Nature, 355:212, 1992.) Comment. Nature has produced many remarkable creatures. They become anomalous only if they cannot be explained as the products of small ... random, cumulative mutations. From Science Frontiers #80, MAR-APR 1992 . 1992-2000 William R. Corliss ...
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... the guidance of a surveyor." (Moliner, E. Ramon; "' I Hiss Therefore I Am'," New Scientist, p. 48, November 11, 1995) Comments. We will enjoy reading the inevitable letters to New Scientist from evolutionists. Probably, too, creationists will now be quoting Moliner. Even so, we see much discussion of "adaptive" or "directed" evolution in the scientific literature these days. See SF#96. This subject is also mentioned frequently in all catalog volumes in the Biology Series (BH, BM, etc.) The volumes in print are described here . From Science Frontiers #103, JAN-FEB 1996 . 1996-2000 William R. Corliss ...
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... , two archeologists faced with the geofact problem at their Pakistan dig, tried to solve it experimentally. They deliberately dropped quartzite rocks from heights onto hard surfaces. They concluded: "While conceding that had we conducted the experiment with a thousand, ten thousand, or a hundred thousand stones, a few might have fractures, we would nevertheless maintain that the chances of any showing multiple, multi-directional flaking and all with bulbs of percussion are as remote as the proverbial monkey typing Shakespeare." (Dennell, Robin, and Hurcombe, Linda; "Comment on Pedra Furada." Antiquity, 69:604, 1995.) From Science Frontiers #105, MAY-JUN 1996 . 1996-2000 William R. Corliss ...
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... to suggest that "psychoevolution" may be physiologically possible. If the brain can fight disease and even control cell growth, why not a role for the mind in stimulating the development of new spe cies, perhaps in response to extreme environmental pressures, and perhaps not on the conscious level? The body's sensory system would detect great external stresses, the brain would process the information, and direct some astute genetic shuffling. The genetic inheritance of an organism is not sacrosanct. Radiation, chemicals, and various others mutagens are recognized. There seems to be no a priori reason why the brainbody combination cannot generate mutagens -- possibly not randomly but intelligently! (We ignore here selfish DNA and Sheldrake's morphogenic fields.) Does this mean that if we wish to mutate, we ... ? Well, it's probably not as simple as wishing warts away, but Maddox's editorial underscores the complexity and subtlety of the brain-body combination. From Science Frontiers #35, SEP-OCT 1984 . 1984-2000 William R. Corliss ...
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... . In fact, lucid dreams were the most common type of anomalous dream. Out-of-body dreams came next. Precognitive dreams were third in frequency. (Krippner, Stanley, and Faith, Laura; "Anomalous Dreams: A Cross-Cultural Study," Society for Scientific Exploration paper, 2000.) Comments. Lucid dreams are especially vivid and, in addition, under the direct control of the dreamer. Actually, all dreams are anomalous in the sense that it is difficult to understand how dreaming evolved. How can a series of small, random mutations introduce these often bizarre images that drift through the not-so-quiescent, sleeping brain? How could dreaming have had enough survival value to our distant ancestors to lock it permanently into the human genome? From Science ... #131, SEP-OCT 2000 . 2000 William R. Corliss Other Sites of Interest SIS . Catastrophism, archaeoastronomy, ancient history, mythology and astronomy. Lobster . The journal of intelligence and political conspiracy (CIA, FBI, JFK, MI5, NSA, etc) Homeworking.com . Free resource for people thinking about working at home. ABC dating and personals . For people looking for relationships. Place your ad free. ...
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... weapons of all involve the outright murder of host chicks. To this end, parasite chicks have evolved some special weapons and behaviors. Some cuckoo chicks evict host eggs or chicks by squirming under them and positioning them in a specially configured hollow on their backs. Then, pushing upward and outward to the rim of the nest, they dump their cargo over the edge. Other brood parasites are more direct and bloodthirsty. "Nestling African honeyguides have bill hooks to stab and kill their nestmates and the brood parasitic American striped cuckoos have independently evolved hooks and pincers to kill." (Payne, Robert B.; "Brood Parasitism in Birds: Strangers in the Nest," BioScience, 48:377, 1998.) Comment. The hollow in the cuckoo's back and the deadly ... on the honeyguide bill disappear once their grisly work is done. Both strategies require bizarre, coordinated innovations in both weapons and behavior. These could, in principle at least, be the work of random mutation and natural selection -- but were they? Is there something we are missing in our theories? Euroasian cuckoo chicks maneuver under host eggs and chicks and dump them over the edge of the nest. Their backs have a neatly designed depression that just fits their potential competitor. (From: Biological Anomalies: Birds) From Science Frontiers #119, SEP-OCT 1998 . 1998-2000 William R. Corliss ...
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... . Guidon and A.-M . Pessis entitled their opening broadside: "Falsehood or Untruth"! They wrote: "The article by Meltzer et al (1994) is based on partial data and false information (highlighted below). Its battery of questions takes us by surprise; none of the three colleagues came up with these questions during the 1993 meeting -- mounted precisely to generate direct dialogue on the peopling of the America. We disagree with their statement, 'the comments on Pedra Furada are not offered lightly' (p . 696). The commentaries are worthless because they are based on partial and incorrect knowledge. "We believe that the initial intention of the authors was different; they got carried away into an exercise in academic style, from a fragile scientific base ... . Guidon, N., et al; "Nature and Age of the Deposits in Pedra Furada, Brazil: Reply to Meltzer, Adovasio & Dillehay," Antiquity, 70:408, 1996. Comment. Continuing our SF#105 analogy between geofacts and biological organisms -- both supposedly products of random processes and subsequent selection -- we ask how long it would take for enough random mutations to accumulate, in the proper order (as with the geofact flake scars) to evolve a new species, with the help of natural selection (corresponding to Guidon et al sorting out their flaked stones)? Millions of years? But perhaps that much time was not available. See under BIOLOGY the two items on the rapidly evolving ciclid fishes of Lake Victoria and "intelligent" genomes. ...
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... in the Fossil Record BME3 Explosive Radiations in Mammalian Evolution BME4 Unexplained Extinctions of Large Mammals BME5 The Failure of Evolution to Improve Mammal Survivability BME6 Anomalously Early Fossils BME7 Track-Like Markings in Ancient Strata BME8 Mammals with Histories Known Only from Subfossils BME9 Anomalous Distribution of Mammalian Skeletal Material BME10 Parallelisms in the Mammalian Fossil Record BME11 Pleistocene Dwarfing of Some Mammals BME12 Variations in Mammalian Teeth and Skeletons Show a Definite Direction Very Early Australian Placental Mammals Eurasian Apes as Ancestors of the Great Apes (and Humans) Aquatic Sloths Evolution of Cetacean Osmoregulation Evolution of Giraffe Necks Bipedal Apes (before Humans) BMF BODILY FUNCTIONS BMF1 Water-Breathing in Mammals BMF2 Remarkable Adaptations in Diving Mammals BMF3 Oddities of Digestion BMF4 Perpetual Growth in Mammals BMF5 Limb Generation in Mammals BMF6 Anomalies of Hibernation in Monotremes BMF7 The "Winter Sleep" ... of Humans BHG13 Human Mitochondria Radically Different from Those of Other Organisms BHG14 Paternal Mitochondrial DNA can Be Inherited BHG15 African Nuclear DNA Is Distinct from That of Other Populations BHG16 Chromosome Banding Analysis Incompatible with DNA Analysis BHG17 Involucrin Analysis Conflicts with Mitochondrial DNA Analysis BHG18 Human Molecular Clocks Run More Slowly Than Those of Apes BHG19 Absence of Transitional Forms of Cytochrome C DNA Analysis and the Origin of Modern Populations High Deleterious Mutation Rates in Hominids Fetal DNA in Mother's Blood Epigenetic Inheritance Unique Human Lack of Retroviruses Neanderthal mtDNA Different Persistence of Cystic Fibrosis Gene Humanity's "Missing" Mutations Persistence of ITD Gene Overall Human Mutation Rates Very Low "Junk" Genes and Human Evolution Curious Genetic Homologies HIV-Like Gene in Human DNA BHH HEALTH BHH1 Health and Environmental Electricity BHH2 Health and Weather BHH3 Disease Epidemics Correlated ...
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