... Computers So, you thought this item was going to be about advances in chips, modems, and related hardware? It's not about software either. It's about bioware. The title of a recent article in Science began with: "Genomic Cis-Regulatory Logic." That's obscure enough to make you move on to the next article, particularly when you see that sea urchins are involved. But buried in all the technical jargon is a profound discovery: The genes of all living things, from sea urchins to humans, are in reality systems consisting of thousands of simple computational devices. Very, very briefly, the regulatory regions for animal genes, are termed "promoters." Promoters typically consist of a few hundred to several thousand bases of DNA. In ... work of Yuh et al, the article's authors, these promoters are seen to perform as logic circuits, just like those bits of silicon in your PC. These tiny, DNA-based biological logic circuits determine how genes are interpreted (each gene may be interpreted in several ways), and, in the end, how lifeforms develop from embryo to adult. (Yuh, Chiou-Hwa, et al; "Genomic CisRegulatory Logic: Experimental and Computational Analysis of a Sea Urchin Gene," Science, 279:1896, 1998. Also: Wray, Gregory A.; "Promoter Logic," Science, 279:1871, 1998.) Comment. Figuring out how your PC's hardware evolved is child's play compared to elucidating just how random mutation ...
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... Science Frontiers ONLINE No. 70: Jul-Aug 1990 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Crystal Engineering Left to themselves, molecules of calcium carbonate tend to crystallize into neat rhombohedrons. But when a sea urchin gets hold of the same molecules, its biological machinery coaxes them into crystallizing into long spines, complete with pores and curved edges. X-ray diffraction patterns prove that the spines are all one crystal . In like fashion, bacteria mold miniature single-crystal bar magnets for navigational purposes. Many animals indulge in crystal engi neering. Now if we can only train organisms to build crystalline electronic devices for us. Biogenic chips? (Mann, Stephen; "Crystal Engineering: The Natural Way," New Scientist, p ... 42. March 10, 1990.) From Science Frontiers #70, JUL-AUG 1990 . 1990-2000 William R. Corliss ...
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