37 results found.
... Science Frontiers ONLINE No. 37: Jan-Feb 1985 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects The genome's responses to challenges The genome is an organism's genetic endowment. It contains instructions for the organism's growth and development, but it is not like a rigid, uncompromising computer program. Rather, the genome: ". .. is a highly sensitive organ of the cell that monitors genomic activities and corrects common errors, senses unusual and unexpected events, and responds to them, often by restructuring the genome. We know about the components of genomes that could be made available for such restructuring. We know nothing, however, about how the cell senses danger and instigates responses to it that often are truly remarkable." Thus Barbara McClintock ends the paper she delivered in Stockholm when she received a Nobel Prize in 1983. Most of McClintock's paper reviews her pioneering work with the corn genome, but she adds some examples of other genomic responses to external stresses. One such stress is applied to an oak tree when a wasp lays its egg in a leaf. The stress causes the oak genome to reprogram itself and construct a wholly new and unplanned plant structure to house and feed the developing insect. Some of these structures (galls) are very elaborate and are precisely tailored to each different wasp species. From such examples, it is apparent that the genome of an organism somehow perceives stresses and reacts to them -- often in completely unanticipated ways. The stresses may be mechanical, thermal ...
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... Science Frontiers ONLINE No. 136: JUL-AUG 2001 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Genome-map User Beware!Omissions. Amid much hullabaloo, it was announced recently that the human genome has now been mapped. To everyone's surprise, we are said to be constructed from blueprints containing only about 30,000 genes. But how accurate are these maps that were drawn up so hastily in the bitterly contested race between the publically and privately sponsored programs? How good are those computer programs that identified these 30,000 or so genes? According to W. Haseltine, who heads Human Genome Sciences, "They're reading smudged text through foggy glasses." Haseltine's company claims to have found more than 90,000 human genes. Two other organizations have identified between 60,000 and 65,000 genes. A research group at Ohio State University at Columbus analyzed the same data used by the public consortium and estimates that there are actually human 80,000 genes! In fact, this groups avers, the public consortium's software seems to have missed 850,000 gene segments for which there already exists protein or RNA evidence. The human genome map seems to harbor many terrae incognitae. So, we best not draw profound conclusions just yet. (Kintisch, Eli; "So What's the Score?" New Scientist, p. 16, May 12, 2001.) Errors. The genome-mapping efforts of both the public consortium and private company (Celera ...
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... Science Frontiers ONLINE No. 139: Jan-Feb 2002 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects How The Genome's Message Can Be Altered Our genomes (complements of genes) can no longer be called sets of instructions like those in a computer program. Demonstrating the veracity of this statement are the following three quotations. Increasingly, a picture of interactivity and multifunctionality among genes is emerging that precludes such a simple one-to-one mapping. Furthermore, the genome can exhibit considerable flexibility to adapt when the expression of a particular gene fails, and the interpretation of a mutant phenotype [life form] is also less trivial than it may seen. "Not only are behavioural phenotypes very sensitive to non-genetic influences," writes [R .] Greenspan, "but also the highly interconnected network of the nervous system sets up an additional layer of complexity between the gene and the realization of the phenotype." (Ref. 1) Many genes code for multiple variants of the same protein. And many proteins are modified by adding sugar molecules, which play a big role in determining where proteins go and what they do. What's more, different proteins can join together to carry out completely new functions. (Ref. 2) A group of French biologists, led by Francois Jacob and Jacques Monod showed that the gene's boundaries are fuzzier than had been thought and that genes are not restricted to chromosomes. Recently, biologists have found genes within genes, overlapping genes, and DNA sequences that ...
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... Science Frontiers ONLINE No. 131: SEP-OCT 2000 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Oh, The Complexity of it All!The headlines say that the human genome has been charted and further imply that we now can read life's total blueprint. Closer study of the announcement reveals that there still remain unreadable snippets of the genome here and there. In fact, the total number of human genes is still in doubt: maybe 30,000, some say 120,000. This wide range of uncertainty does not inspire belief in the accurate readability of this biological blueprint at the present time. Usually left unsaid is the fact that the present blueprint covers only 2-3 % of the territory. That's right, 97-98% of the human genome isn't mapped at all. This uncharted territory is assumed to be "junk" or "nonsense" DNA that plays no role in heredity. Want to bet that this assumption is correct? And don't forget that genes jump around. The genome is really a moving target. Genes also work in concert. It is not one gene coding for one protein, which then has a singular role in creating an operational human being. For example, some 5,692 genes are active in breast-cancer cells. Genes may also have multiple roles. Our present blueprint of the human genome does not display all the mobility and complex interrelationships of the genes. We do know that genes are the blue-prints for the ...
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... Science Frontiers ONLINE No. 129: MAY-JUN 2000 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects A Third Way?A THIRD WAY? In the never-ending, ever-acrimonious "dialog of the deaf" between the Darwinists and the Creationists, we are perpetually exposed to their extreme, non-negotiable positions. The Darwinists insist upon their one-gene/one-protein genome in which random mutations slowly accumulate and adapt living things to the changing environment. The Creationists only accept a one-time, supernatural creation of "kinds" plus minor adaptations (" microevolution"). J.A . Shapiro, a professor at the University of Chicago, is searching for a "third way," a scientific, non-Darwinian way. Shapiro maintains that five decades of genetic and molecular-biology research have transformed our vision of life. Ile compares the conceptual changes to those accompanying the transition from classical physics to relativity and quantum mechanics. This new theory of evolution -- his "third" way -- will emerge from the convergence of biology and information science. Genomes, asserts Shapiro, are not really the static "beads on a string" envisioned by the Darwinians. Rather, they are fluid and complex. Genes are now seen as multipurpose elements that turn on and off as required for the survival and well-being of the organism they belong to. In this paradigm-eroding paper (referenced below), Shapiro describes four categories of molecular discoveries that have revised our thinking about how ...
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... Science Frontiers ONLINE No. 135: MAY-JUN 2001 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Where Is The Maestro?As we learn more and more about the gene complements of our planet's multitudinous life forms, the more it seems that the vaunted genome may not incorporate all of the information necessary to construct a living organism. Despite assurances to the contrary, we must ask if we really know the whole story. These doubts manifest themselves as we see that creatures that are very much alike genetically may be radically different morphologically. In this vein, C. Ventner asserts that all higher vertebrates have roughly the same genes. The animals that result from these re-markedly similar genomes depend upon when specific genes are turned on and off. Ventner says, "We have the same number of genes as cats and dogs, but differently regulated." The genes themselves are supposed to be simply protein factories. Somehow, they are turned on and off (" expressing" themselves) in just the right sequences to help build the target animal. In a far-stretched analogy, the genes are the instruments in an orchestra and the proteins they produce are the notes in a symphony. But where are the symphony's score and its conductor? Very similar orchestras, it seems, can play radically different symphonies given different scores as interpreted by a maestro. Each living thing is likewise a symphony of proteins, each played by the genome at just the right time. But just where are the score -- ...
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... Science Frontiers ONLINE No. 63: May-Jun 1989 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects The Language Of Life Popular writers on biology are fond of saying that the genes and their DNA carry all information necessary for the development of an organism and the transfer of inherited characteristics. With the advent of the multibillion-dollar project to map the human genome (our genetic inventory), we have been seeing this extreme claim more often. The truth is that a map of the human genome will not tell us everything. By way of confirmation, we quote the lead paragraph from a recent article in New Scientist: "In the early days of molecular biology, during the 1950s and 1960s, scientists as much as journalists fuelled the euphoria that surrounded the cracking of the genetic code. The secret of life was revealed, so many people thought. As our understanding has grown, however, so has our awareness of our ignorance. Research at the forefront of the molecular sciences has shown that we can no longer regard DNA - the stuff of genes - as a direct and complete set of instructions for the synthesis of proteins. The evidence begins to suggest that messages in the DNA are, in themselves, no more precise than the symbols and sounds with which we communicate. As in the languages with which we are familiar, the correct sense of a message written in DNA seems to depend on the rigorous checking and correction of errors, and on the context in which they are read." The final sentence of the ...
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... Science Frontiers ONLINE No. 34: Jul-Aug 1984 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Dna Even More Promiscuous It was a surprise when DNA sequences from mitochondria in yeast cells were discovered setting up shop in the nuclear genomes (i .e ., the normal genetic endowment of the cell nucleus). Now biologists find that DNA sequences in many species regularly and frequently hop from one genome to another. Genetic material from cell chloroplasts mix with that of the mitochondria and that of the normal nucleus in what seems to be a free-for-all. This genome hopping has earned DNA the adjective "promiscuous." The significance of DNA promiscuity is to be found in the general belief that the cell's mitochondria and chloroplasts were once independent biological entities that, in the course of life's development, invaded or were captured by cells and have led a symbiotic life ever since. The mitochondria and chloroplasts perform certain important functions in the cell but were thought, until now, to retain considerable genetic independence. (Lewin, Roger; "No Genome Barriers to Promiscuous DNA," Science, 224:970, 1984.) Comment. The promiscuity of DNA raises speculation that other DNA-bearing entities that invade the body, especially the viruses, may transfer their DNA to the host, and conceivably vice versa. With DNA apparently much more promiscuous than believed earlier, the role of disease in the development of life takes on a new importance. In other words, all species can potentially exchange genetic ...
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... Science Frontiers ONLINE No. 108: Nov-Dec 1996 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Those selfish genes may also be intelligent!R. Dawkins has proposed that we humans and other organisms are merely lumbering life-support systems for our genes. In this view, genomes are the masters, controlling our evolution and behavior to ensure their own survival and multiplication. In short, our genes are "selfish." J. Shapiro, at the University of Chicago, has gone a step further and ascribed still another human attribute to genomes. "Genomes function as true intelligent systems, which can be readjusted when conditions require. We still lack testable theories to explain how this can be done. ( Genetica , 84:4 , 1991)" Perhaps we see evidence of this "intelligence" of genes when bacteria and other microorganisms rapidly accommodate to environmental challenges, as in the application of new antibiotics. In this context, read below about the fast-evolving cichlid fishes of Lake Victoria. These fish must have macho genes! From Science Frontiers #108, NOV-DEC 1996 . 1996-2000 William R. Corliss ...
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... Science Frontiers ONLINE No. 116: Mar-Apr 1998 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Eco-Darwinism: Diffuse Individuals Epigenetic phenomena -- those phenomena beyond the pale of DNA -- are seen in "diffuse individuals" such as fungi, where it is difficult to separate individual units of life. To illustrate, some fungi may be 1,000 years old and extend for 35 acres (15 hectares) and yet possess a single, still unmodified genome. In his review of A. Rayner's new book Degrees of Freedom: Living in Dynamic Boundaries , T. Wakeford writes: "So, like the World Wide Web, a fungal network is decentralized. There is no central region capable of exerting control over the rest of the network. Rayner's own work suggests that the growth patterns of fungal filaments are forged as much by the environment that they encounter as by their genes. He believes that epigenetics, the process whereby opportunities in an organism's surroundings dictate which genes are expressed, is the norm in microorganisms. Genetic determinism is thus turned on its head." (Wakeford, Tom; "We Are the Fungus," New Scientist, p. 49, May 10, 1997.) Comment. Looking at the above situation from an information viewpoint, as one must these days, it seems that the environment can somehow "interpret" genes as the situation demands. In other words, genes are not "single-message" information carriers, but can be " ...
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... Science Frontiers ONLINE No. 117: May-June 1998 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects The Evolution Of Computers So, you thought this item was going to be about advances in chips, modems, and related hardware? It's not about software either. It's about bioware. The title of a recent article in Science began with: "Genomic Cis-Regulatory Logic." That's obscure enough to make you move on to the next article, particularly when you see that sea urchins are involved. But buried in all the technical jargon is a profound discovery: The genes of all living things, from sea urchins to humans, are in reality systems consisting of thousands of simple computational devices. Very, very briefly, the regulatory regions for animal genes, are termed "promoters." Promoters typically consist of a few hundred to several thousand bases of DNA. In the work of Yuh et al, the article's authors, these promoters are seen to perform as logic circuits, just like those bits of silicon in your PC. These tiny, DNA-based biological logic circuits determine how genes are interpreted (each gene may be interpreted in several ways), and, in the end, how lifeforms develop from embryo to adult. (Yuh, Chiou-Hwa, et al; "Genomic CisRegulatory Logic: Experimental and Computational Analysis of a Sea Urchin Gene," Science, 279:1896, 1998. Also: Wray, Gregory A.; "Promoter Logic, ...
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... ONLINE No. 112: Jul-Aug 1997 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Archea: Tough And Different Today's textbooks recognize only two main divisions of life: the prokaryotes (cells without nuclei) and eukaryotes (cells with nuclei). Humans and most of the life forms we are familiar with belong to the latter group. (Curiously, human red blood cells lack nuclei!) However, a third basic type of life has been found prospering in some extreme environments. These are the Archea, typified by the methane-producing microbes discovered clustered around hot deepsea vents, where temperatures may exceed 400 C. It is not their rugged constitutions that place these miniscule forms of life in a new category; it is their genomes. They are radically different from those found in prokaryotes and eukaryotes. The genome of one species of Archea collected from a hot vent 3 kilometers deep in the Pacific has been sequenced. Biologists were taken aback. Methanococcus jannaschii , as it has been dubbed, possesses 1738 genes, of which 56% are entirely new to science. Many of these genes do not look anything like those found in the prokaryotes and eukaryotes. In a word, they seem "alien." (Morell, Virginia; "Life's Last Domain," Science, 273:1043, 1996.) How alien? Well, they are so tough that they could have arrived from Mars on a meteorite. Millions of years of residence in a meteorite edging its way toward a rendezvous with earth mean ...
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... Many people have had such observations, but they have problems getting them published." Our template in this discussion is an article by A.S . Moffat in American Scientist. She says, "The stakes in this dispute are high, indeed. If directed mutations are real, the explanations of evolutionary biology that depend on random events must be thrown out. This would have broad implications. For example, directed mutation would shatter the belief that organisms are related to some ancestor if they share traits. Instead, they may simply share exposure to the same environmental cues. Also, different organisms may have different mutation rates based on their ability to respond to the environment. And the discipline of molecular taxonomy, where an organism's position on the evolutionary tree is fixed by comparing its genome to those of others, would need extreme revision." What sort of experiment did Cairns do to cause such a ruckus? In particular, he studied E. Coli bacteria. Normally, these bacteria cannot metabolize the sugar lactose. Cairns exposed the E. Coli to a sudden dose of lactose, demonstrating that if the bacteria must have lactose to survive, they quickly cast off the two genes that inhibit their metabolizing of lactose. Of course, the experiments were more complicated than this, but the fundamental finding was that the bacteria mutated so that they could use lactose much, much faster than chance mutation would permit, stastically speaking. The battle lines are forming. A sup-porter of directed mutation, J. Shapiro, of the University of Chicago, is quoted as follows ...
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... mouse to amoeba are merely DNA's way of manufacturing still more DNA -- so goes the modern ramification of molecular biology and the Genetic Code. In other words, DNA and genes are selfish, and ultimate parasites, directing the evolution of life only to maximize the production of DNA. This theme is not the subject of this paper by Doolittle and Sapienza. Rather, they wonder about those nonsense DNA sequences that do not code for protein. The presence of these "useless" bits of genetic material is often explained in terms of gene "expression." Emphasis is always on maximizing the "fitness" of the organism (phenotype). Perhaps this seemingly excess genetic material actually maximizes the fitness (survivability) of the DNA itself. Evolution thus occurs at DNA and gene (genome) levels, despite what transpires at the organism (phenotype) level. (Doolittle, W. Ford, and Sapienza, Carmen; "Selfish Genes, the Phenotype Paradigm and Genome Evolution," Nature, 284:601, 1980.) Comment. We know that mitochondria and chloroplasts have their own genetic material; evolution may be occurring at this level, too, independent of pressures for change on the organisms. Waxing speculative, may there not be other hierarchies where systems are trying to maximize their own survivability, even at molecular, atomic, and subatomic levels? Don't laugh! Is not all life implicitly encoded in the properties of the most fundamental particles? If not, reductionism is a lie. From Science Frontiers #11, Summer 1980 . 1980-2000 ...
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... Science Frontiers ONLINE No. 150: Nov - Dec 2003 Other pages Home Page Science Frontiers Online All Issues Last Issue Next Issue Sourcebook Project Sourcebook Subjects Contents Archaeology Australians First in the New World? Origin of Clovis Culture Disputed A "Magic Number" Encoded in Three of the World's Major Pyramids Astronomy Mapping and Analyzing Dark Matter Biology Frog Poison Factory Puffin Tongue Trick? Human-chimp DNA Dissimilarities Four-Dimensional Biology A Squid's Eyes that Look Up and Down Tuberculosis and the Extinction of the Megaforna Dark Matter in our Genome Unknown Source of Animal Diversity Communication among Bacteria Geology When the Earth Gets Cracking Subduction Doesn't Check Out Chicxulub Didn't Do It! Geophysics Squishy Ball Lightning Far-Floating Fowl Psychology Natural-Born Readers Physics Mixed Anomalies ...
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... Science Frontiers ONLINE No. 134: MAR-APR 2001 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects What Sang First?Not WHO, but WHAT! Sophisticated music predates the advent of modern humans by tens or hundreds of million years. Whales and birds filled the ocean and primeval forest with song long before our hominid branch sprouted on the Tree of Life. As a matter of fact, our closest relatives, the great apes, sing not at all. Somewhere in the hominid genome "music" genes reside, unexpressed in the apes, but somehow triggered into activity in the human line. We have learned recently that the Neanderthals manufactured bone flutes as far back at 53,000 years. They may not have been able to speak to one another in words, but they had the language of music. Their music, and ours, may have been entrained in genes inherited from nonhominid ancestors that lived 60 million years ago, but which have been suppressed in primates until Neanderthals and modern humans came along. You may wonder where this argument is taking you. It goes back at least 60 million years to when the cetacea (whales and dolphins) split off from the evolutionary track leading to humans. It may even go back farther to when birds split away from the reptilian line. The music of birds and whales incorporate some of the complexity and sophistication of Beethoven's Fifth. The genes that have led to such musical talents may be ancient indeed, as speculated in the Science article under review. The authors go ...
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... Science Frontiers ONLINE No. 37: Jan-Feb 1985 Other pages Home Page Science Frontiers Online All Issues Last Issue Next Issue Sourcebook Project Sourcebook Subjects Contents Archaeology A Disaster-driven Early Civilization Another Remarkable Specimen of Ancient Man Astronomy The Puzzle of the Moon's Origin When Mars Had Lakes Why Aren't the Martian Craters Worn Down? Flip-flop Radio Jets? Biology The Genome's Responses to Challenges "hopeful Monsters" in Iceland? Parasites May Reprogram Host's Cell Geology More Doubts About Asteroids The Earth is Expanding and We Don't Know Why The Grand Canyon Conundrum Evidence for A Giant Pleistocene Sea Wave Recent Pulsations of Life Geophysics "Crystal" Ball Lightning The Big Divot! Shower of Coke Chemistry & Physics Squarks and Photinos At Cern? What Does it All Mean? The Secret of it All is in the Pi ...
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... Science Frontiers ONLINE No. 96: Nov-Dec 1994 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects "ADAPTIVE" MUTATION Six years ago, J. Cairns performed experiments with bacteria that implied that said bacteria could "direct" their own mutations so that they could cope more speedily with sudden environmental trauma. (SF#64) In Cairns' experiments, bacteria unable to digest lactose were presented with an all-lactose diet. They quickly acquired the mutations needed to digest the only food available. They did not have to wait for random mutations to accidentally hit upon the correct genome changes. A firestorm spread across the scientific community, even though other researchers saw similar effects. It was traumatic! One of science's foundation stones was at risk. The current theory of biological evolution insists that all mutations are random. Cairns believed he had shown that his bacteria experienced only useful mutations. This claim was too awful to accept. In the July 21, 1994, issue of Science, two new papers appeared that, while not proving that only useful mutations occur in Cairns-type experiments, do indicate that something unusual is indeed happening. Basically, when bacteria are under stress (say, starving), a "distinctive" type of mutation occurs! Is "distinctive" a code word for "non-random"? The title of the commentary accompanying the two articles says it all. (Culotta, Elizabeth; "A Boost for 'Adaptive' Mutation," Science, 265:318, 1994. ...
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... Science Frontiers ONLINE No. 153: May - Jun 2004 Other pages Home Page Science Frontiers Online All Issues Last Issue Next Issue Sourcebook Project Sourcebook Subjects Contents Archaeology 5,500-year-old Clusters of Stone Pillars Rock Art and Rock Music Bog Butters Astronomy Parallel Double Meteor Trails Martian Bunnies? Inflation Inflated Biology Genome Fusion in Radically Different Species Animal Fasting in the Wild Nanotubular "Highways" Connect and Trap Cells Geology Hydroplaning in Geology Sand Dunes Invisible at Ground Level Another "Cookie-Cutter" Event Geophysics Will-O -The-Wisps Sicilian Sparks Psychology A Strange Property of Hyperlexia Chemistry The Darwinian Breeding of Nanostructures One "Pathological Science" May Not Be So Sick After All! ...
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... Science Frontiers ONLINE No. 139: Jan-Feb 2002 Other pages Home Page Science Frontiers Online All Issues Last Issue Next Issue Sourcebook Project Sourcebook Subjects Contents Archaeology Who Needs Boats Confusion that's Hard to Cut Through Astronomy The Spheres can Dance to Convoluted Music White Mars? Ghostly Martian "Forrests" Biology How the Genome's Message can be Altered The Second Genetic Code and Apparently a Third The Mysterious First Green Egg Geology When the Edges of the Continents were Naked Unstable Earth Really High Oysters Geophysics Surf's Up on Californian Shores: Really up at Cortes Bank Tunguska: An Inside Job? Rock-fall Air Blasts Psychology And the Machines Wept for Man ...
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... Science Frontiers ONLINE No. 136: Jul-Aug 2001 Other pages Home Page Science Frontiers Online All Issues Last Issue Next Issue Sourcebook Project Sourcebook Subjects Contents Archaeology The Path of the Pyramids Were the First Americans Australians? Bacon Bits Astronomy Mirror Matter May Matter 2000 CR105 and Planet X Biology Grunting Transcends Biological and Geographical Boundaries Genome-Map User Beware Are We Merely Fancy Crystals? Geology An Ice Ring in a Canadian Pond The Stealth Catastrophe Geophysics Fiery Exhalations in Wales More Carolina Beach Booms Lake Michigan's Annual Silt Plume Psychology The Eclipsing of Innate Talents Songs in Your Head Astrobiology The Forests of Mars ...
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... Sourcebook Project Sourcebook Subjects Evolution By Numbers The following paragraph is taken from a letter to Nature by a "practising geneticist." "In the discussion in your columns about the application of quantitative methodology based on the study of evolutionary processes to the analysis of the development of human culture, there is an unquestioned assumption on both sides of that issue that quantitative theory, as expounded by practitioners such as Fisher, Haldane, Wright, Cavalli-Sforza and Maynard Smith, has been successful in illuminating and explaining the process of biological evolution and the genetic relationships between species. As far as I know, there is no evidence to support this assumption. Indeed, there is a vast number of observations unaccounted for in the extant quantitative evolutionary theories. Many of these observations (inducible mutation systems, rapid genomic changes involving mobile genetic elements, programmed changes in chromosome structure) challenge the most fundamental assumptions which these evolutionary theories make about the mechanisms of hereditary variation and the fixation of genetic differences." (Shapiro, James A.; "Evolution by Numbers," Nature, 303:196, 1983.) Comments. The "observations unaccounted for" are buried in such obscure journals as S.B . ges. Morph. Physio. (Munchen). It is pretty obvious that the Sourcebook Project is just scratching the surface. From Science Frontiers #28, JUL-AUG 1983 . 1983-2000 William R. Corliss ...
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... ) exuding from lesions on the leaves, accidentally pick up some fungus spores, and then fly off to true blueberry blossoms. The transferred spores infect other blueberry plants, causing them to produce white mummy-berries rather than blueberries. When spring comes round, the fungus-filled mummy-berries release the fungus to the leaves, and the cycle continues. (Anonymous; "A Fungus That Courts with Phony Flowers," Science 85, 6:10, September 1985.) Comment. The explanations usually served up for such remarkable adaptations are: (1 ) It is the product of chance and natural selection; and (2 ) The Creator made things this way. Are there not other possibilities? Perhaps the fungus somehow stole the blueprints for the flower from the blueberry's genome; i.e ., genetic endowment. After all, viruses are always subverting cell machinery. From Science Frontiers #42, NOV-DEC 1985 . 1985-2000 William R. Corliss ...
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... very happy in such extreme environments as the salty Dead Sea and the sea-bottom, hydrothermal vents; the latter prosper in bad hamburgers and your gut. Despite their differences, they have always been thought to have evolved from a common ancestor. A more subtle, fundamental difference has now been found. Recall SF#117 and how some terrestrial life forms do incorporate right-handed molecules in their structures, especially in cell membranes? The ubiquitous Eubacteria do this. In the Archaea, however, the same structural components of the cell membranes (glycerophosphates) are left-handed. A subtle difference, but one with deep implications. Some scientists maintain that it is impossible for two organisms relying upon mirror-image versions of the same molecule to have evolved from a common ancestor. Their genomes must be fundamentally different. Conclusion: the Archaea and Eubacteria must have evolved separately, and from different biological wellsprings -- that is, "creations." Such thinking is anathema. M. Kates, a Canadian evolutionary biologist, is skeptical. "Both the physics and chemistry of membranes are so complex that I would regard it as highly improbable that they could have auto-assembled twice." (Barnett, Adrian; "The Second Coming," New Scientist, p. 19, February 14, 1998.) Comment. Both opinions rely upon wild probability guesses, as do all opinions regarding the creation and evolution of life. From Science Frontiers #118, JUL-AUG 1998 . 1998-2000 William R. Corliss ...
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... all, we have about 100,000 genes per cell. Of course, mitochondria do evolve separately from us, and this is a bit disconcerting. Could they be more than mere symbionts? The midi-chlorians of the Jedi knights were "good guys", but our mitochondria sometimes seem to be working for an insidious alien Force. There is good evidence that they: Selected which of your mother's germ cells matured to produce you; Have decided your odds of living to be 100; and May influence your being afflicted with Parkinson's and Alzheimer's , as well as rarer disorders. The first item (or "force") is the most disturbing. Mitochondria (with only 35 genes), it seems, can exercise vetoes over decisions by our own genome (with its 100,000 genes). (Cohen, Philip; "The Force," New Scientist, p. 30, February 26, 2000.) The cells of higher organisms are busy places. One of this cell's mitochondria is indicated at the lower right, but there are several others in the sketch. They have their own DNA (mtDNA). Comment. It is disconcerting to realize that within each of our cells hundreds of alien entities, though helpfully supplying energy, are mutating and evolving in ways to enhance their fitness rather than ours. Like so many true parasites, mitochondria will not shrink from modifying their hosts (us!) to achieve their ends -- whatever they are. The Force seems to be with them! From Science Frontiers ...
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... amoebas are transformed into a radically different entity. One wonders how this superorganism, this slime mold, is controlled. Where are its sensors and its information processing center, if it possesses one? (Stewart, Ian; "Spiral Slime," Scientific American, 283:116, November 2000.) This question becomes more difficult to answer when we learn that slime molds can display rudimentary intelligence in the sense that they can solve mazes in their search for food. They are not as clever as rats, but they do optimize their travels through the maze. (Nakagaki, Toahiyuki, et al; "Maze-Solving by an Amoeboid Organism," Nature, 407:470, 2000.) Biofilms. Down near the bottom of life's ladder dwell the bacteria. Their genomes must be miniscule and gray matter is not to be found. Nevertheless, some bacteria band together to form biofilms. Biofilms are three-dimensional, complex structures composed of innumerable, specialized bacteria all working together. W. Costerton at Montana State University imagines what a biofilm would look like if one were bacterium-size. If you found yourself in a biofilm, you'd be going along a channel full of water, like the canals in Venice, and up from the bottom of the channel, on either side, would be these slime towers. The channels would be bringing in oxygen and nutrients. and removing waste. And within each building, so to speak, some of the bacteria would be cooperating with each other, making one compound and passing it along to the ...
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... footpaths follow many of the Nazca lines. Accumulating evidence has led many archeologists and anthropologists to conclude that some of the Nazca lines are ritual pathways, meant to be walked upon and to lead processions to spots where prayers for more water would be most effective. The geoglyphs, however, remain mysterious. (McClintock, Jack; "The Nasca Lines Solution," Discover, 21:74, December 2000.) Comments. The Nazca lines have not been neglected in past newsletters. See SF#47 and SF#63. Ritual processions like those hypothesized for the Nazca Plain resemble thosethought to have taken place along Avebury's avenue, Carnac's stone rows, and Chaco Canyon's mysterious converging system of "roads." Ritual processions seem to be built into the human genome. From Science Frontiers #134, MAR-APR 2001 . 2001 William R. Corliss Other Sites of Interest SIS . Catastrophism, archaeoastronomy, ancient history, mythology and astronomy. Lobster . The journal of intelligence and political conspiracy (CIA, FBI, JFK, MI5, NSA, etc) Homeworking.com . Free resource for people thinking about working at home. ABC dating and personals . For people looking for relationships. Place your ad free. ...
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... ." This controversial phenomenon is termed "adaptive mutation." (SF#64 and SF#96*) A recent issue of Science presents two more papers that seem to confer the gift of sight on the old Watchmaker. Biochemist J.A . Shapiro, in a commentary accompanying the two Science papers, highlights a significant feature of adaptive mutation in bacteria: The genetic changes involved are multicellular. In other words, DNA rearrangements in one cell are actually transferred to other cells. But most profound of all for the whole science of biology is his sentence: "The discovery that cells use biochemical systems to change their DNA in response to physiological inputs moves mutation beyond the realm of 'blind' stochastic events and provides a mechanistic basis for understanding how biological requirements can feed back onto genome structure." (Shapiro, James A.; "Adaptive Mutation: Who's Really in the Garden?" Science, 268:373, 1995.) Comment. Random mutation has been a linchpin of Neo-Darwinism because it is "scientific"; that is, non-supernatural. We see in adaptive mutation that other scientific mechanisms may indeed exist that make biological evolution more than just a plaything of chance. Furthermore, since some species (You know who you are!) can modify environmental forces, these species can, in principle, control their own evolution -- for good or bad -- and may in fact be doing just that. *SF#xx = Science Frontiers #xx. From Science Frontiers #100, JUL-AUG 1995 . ...
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... defined in the abstract. In fact, lucid dreams were the most common type of anomalous dream. Out-of-body dreams came next. Precognitive dreams were third in frequency. (Krippner, Stanley, and Faith, Laura; "Anomalous Dreams: A Cross-Cultural Study," Society for Scientific Exploration paper, 2000.) Comments. Lucid dreams are especially vivid and, in addition, under the direct control of the dreamer. Actually, all dreams are anomalous in the sense that it is difficult to understand how dreaming evolved. How can a series of small, random mutations introduce these often bizarre images that drift through the not-so-quiescent, sleeping brain? How could dreaming have had enough survival value to our distant ancestors to lock it permanently into the human genome? From Science Frontiers #131, SEP-OCT 2000 . 2000 William R. Corliss Other Sites of Interest SIS . Catastrophism, archaeoastronomy, ancient history, mythology and astronomy. Lobster . The journal of intelligence and political conspiracy (CIA, FBI, JFK, MI5, NSA, etc) Homeworking.com . Free resource for people thinking about working at home. ABC dating and personals . For people looking for relationships. Place your ad free. ...
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... . 2. Guidon, N., et al; "Nature and Age of the Deposits in Pedra Furada, Brazil: Reply to Meltzer, Adovasio & Dillehay," Antiquity, 70:408, 1996. Comment. Continuing our SF#105 analogy between geofacts and biological organisms -- both supposedly products of random processes and subsequent selection -- we ask how long it would take for enough random mutations to accumulate, in the proper order (as with the geofact flake scars) to evolve a new species, with the help of natural selection (corresponding to Guidon et al sorting out their flaked stones)? Millions of years? But perhaps that much time was not available. See under BIOLOGY the two items on the rapidly evolving ciclid fishes of Lake Victoria and "intelligent" genomes. Crude stone tools like this are certain signs of human presence -- except when paradigms dictate otherwise! This one is a "bona fide" tool from New Guinea. From Science Frontiers #108, NOV-DEC 1996 . 1996-2000 William R. Corliss ...
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... as with mimics of the Monarch Butterfly. That is, there seems to be no evolutionary advantage to looking alike. (Miller, Julie Ann; BioScience, inside front cover, March 1994. Miller's editorial remarks are based upon a later article by H.F . Nijhout, who also supplied the photographs. Nijhout's article explains how butterfly wing patterns may have evolved.) Comment. Cases of remarkable mimicry also occur among geographically separated species. For example, the North American Meadowlarks are dead ringers for the African Yellow-throated Longclaw. "Convergent evolution" names the phenomenon but doesn't tell how or why long chains of random mutations can come up with the same designs where there seems to be no "guidance" by the forces of natural selection. Perhaps genomes contain "subprograms" for those patterns and structures often used in biology. Of course, Sheldrake's idea of "morphic resonance" also applies here! From Science Frontiers #95, SEP-OCT 1994 . 1994-2000 William R. Corliss ...
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... compass; that is, they chart their courses by noting the sun's changing azimuth. This feat requires not only the measurement of solar azimuth but also reference to an internal clock. Humans cannot do this without artificial instruments. Furthermore, even on cloudy days, migrating monarchs fly in the proper direction (generally south-southwest). Apparently, they also have evolved a backup navigation system, perhaps a geomagnetic compass. (Perez, Sandra M., et al' "A Sun Compass in Monarch Butterflies," Nature, 387:29, 1997.) Comment. Somewhere in the tiny bodies of the monarchs are packed sun-azimuth sensors, internal clocks, magnetic-field sensors, and a nervous system that converts the incoming data into signals to the wings. Their genomes must also include map information to pass on to their progeny. From Science Frontiers #116, MAR-APR 1998 . 1998-2000 William R. Corliss ...
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... has been by-passed as geneticists have focussed on the genes. Cohen and Stewart summarize their views as follows: "What we have been saying is that DNA space is not a map of creature space. There is no unique correspondence between the two spaces, no way to assign to each sequence in DNA space a unique animal that it "codes for." Biological development is a complicated transaction between the DNA "program" and its host organism, neither alone can construct a creature and neither alone holds all the secrets, not even implicitly." (Cohen, Jack, and Stewart, Ian; "Our Genes Aren't Us," Discover, 15:78, April 1994.) Comment. If "genes aren't us" the billion-dollar human genome project cannot fulfill its promises. From Science Frontiers #94, JUL-AUG 1994 . 1994-2000 William R. Corliss ...
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... - not us! (SF#11) Now we learn about "gene wars." As is well known, genes are thought to control much of what goes on in a living organism. But are they only carriers of hereditary information? Not according to a long, very technical paper by L.D . Hurst et al. It seems that, like selfish DNA, genes have their own agendas. The insidiousness of this is seen in the first sentence of the paper's abstract: "Self-promoting elements (also called ultraselfish genes, selfish genes, or selfish genetic elements) are vertically transmitted genetic entities that manipulate their "host" [as in "us'] so as to promote their own spread, usually at a cost to other genes within the genome." You may not sense it, but your genes are struggling with each other, and you and/or your progeny will carry out the dictates of the victors of the "gene wars." (Hurst, Laurence D., et al; "Genetic Conflicts," Quarterly Review of Biology , 71:317, 1996.) Comment. Given the power that these "selfish genetic elements" can exert on our bodies, it is but a short step to imagining that they can also direct the course of evolution in ways favorable to their agendas. In this interpretation, humans have evolved and are conscious and intelligent because these things are favorable to those genes that have conquered in the "gene wars." Natural selection seems to work at many levels in biology! ...
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... ' Furthermore, Cairns' claims recall the long battle with Lamarckism, a subject that biology has closed-the-book-on. In a nutshell, Lamarckism has been interred since the 1950s, and 'Nobody wants to give the appearance of straying from the neoDarwinism fold.' Gillis goes on to review some recent experiments supporting those of Cairns. But, impressive though these may be, there have been neo-Darwinian explanations for some of the results. Even so, more and more biologists are now willing to accept at least the possibility of non random mutation of bacteria. But, in the end, all participants in the debate recognize a great void: There exists no acceptable mechanism by which a life form can steer its own evolutionary way; that is, shape its own genome. What besides natural selection can do this? (Gillis, Anna Maria; "Can Organisms Direct Their Own Evolution?" BioScience, 41:202, 1991.) From Science Frontiers #75, MAY-JUN 1991 . 1991-2000 William R. Corliss ...
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... compilation of a list of scientific phenomena worthy of further attention and research The presentation of a "first look" a the entire spectrum of what I have found anomalous, provocative, and exciting in science The provision, via a menu-type index, of a guide to my many already published Catalogs and Handbooks of anomalies and curiosities. Major Paradigms Targeted Anomalies exist only when they challenge paradigms and hypotheses. It is unavoidable, therefore, that some paradigms, widely considered to be fact, will be contradicted by many of the phenomena listed in this Outline. For example, the following paradigms that presently dominate scientific thinking are her considered to be at risk: The expanding universe The Big Bang origin of the universe Neo-Darwinism (specifically, evolution via random mutation and natural selection) That genomes are the complete blueprint for lifeforms Plate tectonics/continental drift Special and General Relativity View Cart Buy online via PayPal with MC/Visa/Amex 296 pages, softcover, $17.95, 244 illus., Jan 2003. ISBN 0-915554-45-3 , 7x10". Biology Catalogs For a full list of biology subjects, see here . Biological Anomalies: Humans I: A Catalog of Biological Anomalies Sorry, Out of print This volume, the first of three on human biological anomalies, looks at the "external" attributes of humans (1 ) Their physical appearance; (2 ) Their anomalous behavior; and (3 ) Their unusual talents and faculties. Typical subjects covered: Mirror-image twins * The sacral spot * The supposed human aura * Baldness ...
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... of the Sleep Cycle BHF33 Voluntary Suspended Animation BHF34 Human Mortality Correlated with Geomagnetic Activity BHF35 Nearly-Simultaneous Deaths of Twins BHF36 Curious Attitudes after Death Geophagy in Pregnancy and Health Evolution of Menopause Uncertain Purpose of REM Sleep Curious Nature of Anesthesia Evolution of Menstruation Fetal Growth Correlated with Solar Activity Evolution of Sex Purpose of Life after Menopause Decline in Sperm Counts Fetus Signals Timing of Birth How Embryo Development Is Controlled and Effected Cycles in Autistic Births Rhythms in Growth Evolution of Lactose Tolerance Twins and Occurrence of Nightmares Timing of the End of Sleep BHG HUMAN GENETICS BHG1 Human Chromosomes Less Evolved Than Ape Chromosomes BHG2 The Presence of Introns in Human Chromosomes BHG3 Human Chromosomes Lack the "Baboon Marker" BHG4 Y-Chromosome Analysis Suggests First Humans Were Pygmies BHG5 Human and Ape Chromosome Numbers Differ BHG6 Identical Twins May Have Different Genomes BHG7 Gene Imprinting: Parental Influence on Genes BHG8 The Accentuation of Inherited Traits in Succeeding Generations BHG9 Higher Variability of Mitochondrial DNA in Subsaharan Africans BHG10 Mitochondrial DNA Evolves Much Faster Than Nuclear DNA BHG11 Disparity between Human and Ape Phenotypes and Genotypes BHG12 Chimpanzee Mitochondrial DNA More Diverse Than That of Humans BHG13 Human Mitochondria Radically Different from Those of Other Organisms BHG14 Paternal Mitochondrial DNA can Be Inherited BHG15 African Nuclear DNA Is Distinct from That of Other Populations BHG16 Chromosome Banding Analysis Incompatible with DNA Analysis BHG17 Involucrin Analysis Conflicts with Mitochondrial DNA Analysis BHG18 Human Molecular Clocks Run More Slowly Than Those of Apes BHG19 Absence of Transitional Forms of Cytochrome C DNA Analysis and the Origin of Modern Populations High Deleterious Mutation Rates in Hominids Fetal DNA in Mother's Blood Epigenetic Inheritance Unique Human Lack of Retroviruses Neanderthal mtDNA Different Persistence ...
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