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... Science Frontiers ONLINE No. 40: Jul-Aug 1985 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Genetic code not universal!Most current textbooks pronounce that the genetic code is not only universal to life but that it must. Alterations in the code, the reasoning goes, would garble genetic messages. Such dogma, however, is based on another dogma, which states that all life on earth derives from a single ancestral line in which the genetic code is fixed and has always been fixed -- a "frozen" accident hit upon "by chance" on the primitive earth. Recently, though, small deviations from the code have turned up in ciliated protozoons and mycoplasmas, much to everyone's surprise. (Scott, Andrew ... "Genetic Code Is Not So Universal," New Scientist, p. 2l, April 11, 1985.) Comment. No major deviations from the standard genetic code have been found; but then no one has really looked, because everyone knew the code was universal. It would be quite a shock if terrestrial life were found to have several genetic foundations and as many schemes of evolution. From Science Frontiers #40, JUL-AUG 1985 . 1985-2000 William R. Corliss ...
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... Science Frontiers ONLINE No. 139: Jan-Feb 2002 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects The Second Genetic Code And Apparently A Third Genes may or may not be switched on depending upon the addition of molecules called "methyl groups" to DNA. Now, a second kind of gene switch has been discovered on histones, a class of proteins. Figuring out when methylation of histones takes place has far-reaching implications; acting as a second genetic code, histone methylation may determine genetic traits such as the susceptibility to disease. (Martindale, Diane; "Genes Are Not Enough," Scientific American, 285:22, October 2001.) Comment. So, beyond the first genetic code (the DNA) and the ... genetic code (the recognized methyl groups), we now have some proteins (the histones) getting in on the act. And the show ain't over yet! From Science Frontiers #139, Jan-Feb 2002 . 2001 William R. Corliss Other Sites of Interest SIS . Catastrophism, archaeoastronomy, ancient history, mythology and astronomy. Lobster . The journal of intelligence and political conspiracy (CIA, FBI, JFK, MI5, NSA, etc) Homeworking.com . Free resource for people thinking about working at home. ABC dating and personals . For people looking for relationships. Place your ad free. ...
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... Science Frontiers ONLINE No. 11: Summer 1980 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Hierarchies Of Evolution All organisms from man to mouse to amoeba are merely DNA's way of manufacturing still more DNA -- so goes the modern ramification of molecular biology and the Genetic Code. In other words, DNA and genes are selfish, and ultimate parasites, directing the evolution of life only to maximize the production of DNA. This theme is not the subject of this paper by Doolittle and Sapienza. Rather, they wonder about those nonsense DNA sequences that do not code for protein. The presence of these "useless" bits of genetic material is often explained in terms of gene "expression." Emphasis is always on maximizing the " ... " of the organism (phenotype). Perhaps this seemingly excess genetic material actually maximizes the fitness (survivability) of the DNA itself. Evolution thus occurs at DNA and gene (genome) levels, despite what transpires at the organism (phenotype) level. (Doolittle, W. Ford, and Sapienza, Carmen; "Selfish Genes, the Phenotype Paradigm and Genome Evolution," Nature, 284:601, 1980.) Comment. We know that mitochondria and chloroplasts have their own genetic material; evolution may be occurring at this level, too, independent of pressures for change on the organisms. Waxing speculative, may there not be other hierarchies where systems are trying to maximize their own survivability, even at molecular, atomic, and subatomic levels? Don't laugh! Is ...
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... All Issues This Issue Sourcebook Project Sourcebook Subjects The Unread Biotic Message We have been selling ReMine's book The Biotic Message in which he asserts that life itself is a message of transcendental nature. Every bacterium and human is a cosmic statement. Shifting from the macroscopic to the microscopic (phenotype to genotype), we recall that all macroscopic "statements" are really expressions of DNA -- the genetic code. But when we examine DNA, we find that only about 3% of the DNA in human cells codes for protein manufacture. The remaining 97% is termed "nonsense" or "junk" DNA. But there may actually be sense in nonsense DNA. Statistical analysis of nonsense-DNA "words" (3 -8 bases long) reveals considerable redundancy. Long stretches of ... DNA are definitely not random. In fact, the structure of nonsense DNA resembles that of language. The coding or "sense" DNA, on the other hand, lacks this language structure. The implication is that coding and nonsense DNAs carry different kinds of messages. The former consists simply of blueprints; the latter is couched in a language that we have not yet learned to read. (Flan, Faye; "Hints of a Language in Junk DNA," Science, 266:1320, 1994.) Comment. On the microscopic level, we can read only 3% of the biotic message! From Science Frontiers #117, MAY-JUN 1998 . 1998-2000 William R. Corliss ...
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... . 63: May-Jun 1989 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects The Language Of Life Popular writers on biology are fond of saying that the genes and their DNA carry all information necessary for the development of an organism and the transfer of inherited characteristics. With the advent of the multibillion-dollar project to map the human genome (our genetic inventory), we have been seeing this extreme claim more often. The truth is that a map of the human genome will not tell us everything. By way of confirmation, we quote the lead paragraph from a recent article in New Scientist: "In the early days of molecular biology, during the 1950s and 1960s, scientists as much as journalists fuelled the euphoria that surrounded the cracking ... the genetic code. The secret of life was revealed, so many people thought. As our understanding has grown, however, so has our awareness of our ignorance. Research at the forefront of the molecular sciences has shown that we can no longer regard DNA - the stuff of genes - as a direct and complete set of instructions for the synthesis of proteins. The evidence begins to suggest that messages in the DNA are, in themselves, no more precise than the symbols and sounds with which we communicate. As in the languages with which we are familiar, the correct sense of a message written in DNA seems to depend on the rigorous checking and correction of errors, and on the context in which they are read." The final sentence of the article is really paradigm-shaking ...
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... Science Frontiers ONLINE No. 77: Sep-Oct 1991 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Do birds use genetic maps during migration?Routes taken by migrating German and Austrian blackcaps en route to Africa. Hybrids bisect these initial paths and would end up in the Alps. Many young birds migrate successfully without help from older birds who have made the trip before. The implication is that migration instructions, perhaps even some sort of map of astronomical or geo graphical references, are somehow written upon the genes inherited from their parents. Just how maps can be coded into gene structure is anyone's guess. (In fact, since the DNA in the genes seems to cody only for protein synthesis, the locations and characters of inheritable ... and other biological instructions are not immediately obvious.) The problem has been exacerbated by recent experiments with German and Austrian blackcaps. These two common European warbler species take different routes to Africa in the winter. The Ger-man blackcaps fly southwest and the Austrian southeast--routes 50 apart. A. Helbig has crossed the German and Austrian blackcaps to see what route(s ) their hybrid offspring would take. Curiously, they favored a route intermediate between those of their parents. The hybrids' route -- bisecting those of the parents' -- would take the hybrids right into the Alps, where survival would be unlikely. (Day, Stephen; "Migrating Birds Use Genetic Maps to Navigate," New Scientist, p. 21, April 21, 1991.) Comment ...
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... Science Frontiers ONLINE No. 10: Spring 1980 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Dynamic Dna Smugness over our discovery of the genetic code and some simple features of biological synthesis has recently been undermined by the recognition that the so-called nonsense segments in genes may be important after all. Now comes the realization that the DNA molecule may not be a staid, static construction. Travelling kinks and other disturbances seem to play some unknown role in biological recognition. Some biochemists have even suggested that DNA winds and unwinds or "breathes" like a living thing as it helps to manufacture biological substances. (Spencer, Michael; "Bent DNA," Nature, 281:631, 1979.) Comment. The addition of the time ... to biological synthesis evokes thoughts of oscillating systems, frequency dependence, filters, etc. Perhaps Nature has invented something better than the silicon chip. From Science Frontiers #10, Spring 1980 . 1980-2000 William R. Corliss ...
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... Science Frontiers ONLINE No. 48: Nov-Dec 1986 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects The Cosmic Chemistry Of Life C. Ponnamperuma, at the University of Maryland, speculates that the genetic code employed by earth life may, in fact, reflect a universal chemistry. His lab data "suggest that the formation and linking of life's building blocks -- amino acids and nucleotides -- may have been all but inevitable, given the starting chemistry of earth's 'primordial soup.'" Going even further Ponnamperuma believes that "if there is life elsewhere in the universe, chemically speaking it would be very similar to what we have on earth." (Raloff, J.; "Is There a Cosmic ... of Life?" Science News, 130:182, 1986.) From Science Frontiers #48, NOV-DEC 1986 . 1986-2000 William R. Corliss ...
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... Science Frontiers ONLINE No. 139: Jan-Feb 2002 Other pages Home Page Science Frontiers Online All Issues Last Issue Next Issue Sourcebook Project Sourcebook Subjects Contents Archaeology Who Needs Boats Confusion that's Hard to Cut Through Astronomy The Spheres can Dance to Convoluted Music White Mars? Ghostly Martian "Forrests" Biology How the Genome's Message can be Altered The Second Genetic Code and Apparently a Third The Mysterious First Green Egg Geology When the Edges of the Continents were Naked Unstable Earth Really High Oysters Geophysics Surf's Up on Californian Shores: Really up at Cortes Bank Tunguska: An Inside Job? Rock-fall Air Blasts Psychology And the Machines Wept for Man ...
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... . Increasingly, a picture of interactivity and multifunctionality among genes is emerging that precludes such a simple one-to-one mapping. Furthermore, the genome can exhibit considerable flexibility to adapt when the expression of a particular gene fails, and the interpretation of a mutant phenotype [life form] is also less trivial than it may seen. "Not only are behavioural phenotypes very sensitive to non-genetic influences," writes [R .] Greenspan, "but also the highly interconnected network of the nervous system sets up an additional layer of complexity between the gene and the realization of the phenotype." (Ref. 1) Many genes code for multiple variants of the same protein. And many proteins are modified by adding sugar molecules, which play a big role in determining where proteins ... and what they do. What's more, different proteins can join together to carry out completely new functions. (Ref. 2) A group of French biologists, led by Francois Jacob and Jacques Monod showed that the gene's boundaries are fuzzier than had been thought and that genes are not restricted to chromosomes. Recently, biologists have found genes within genes, overlapping genes, and DNA sequences that specify one protein when read "forward" and another when read "in reverse." Muddling things further, the instructions encoded in the DNA do not always reach the ribosome as a literal translation. In a phenomenon known as RNA editing, an enzymatic highwayman intercepts the RNA message en route and alters it, so the resulting protein is not identical to that specified by the DNA ...
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... bats are pri-mates. Furthermore, molecular studies are also negative. Therefore, possibility #1 above is the more likely one. (Martin, R.D .; "Are Fruit Bats Primates?" Nature, 320:482, 1986.) Comment. In either case, #1 or #2 , we must acknowledge convergent evolution and the likelihood that some subroutine in the genetic code repeats itself in divergent species. Speculative as always, we must ask if the genetic instructions for human or even superhuman intelligence do not reside dormant-for-now in other species. Reference. For more on megabat similarities to primates, go to BMC4 in the catalog volume: Biological Anomalies: mammals II. Ordering information here . An epaulleted fruit bat. (Adapted from the McGraw ... Hill Encyclopedia of Science and Technology) From Science Frontiers #46, JUL-AUG 1986 . 1986-2000 William R. Corliss ...
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... narrow view of heredity. Do our genes really contain all the information necessary for constructing human bodies? In the April 1994 issue of Discover, J. Cohen and I. Stewart endeavor to set us straight. The arguments against the "genes-are-everything" paradigm are long and complex, but Cohen and Stewart also provide some simple, possibly simplistic observations supporting a much broader view of genetics. Mammalian DNA contains fewer bases than amphibian DNA, even though mammals are considered more complex and "advanced." The implication is that "DNA-as-a -message" must be a flawed metaphor. Wings have been invented at least four times by divergent classes (pterosaurs, insects, birds, bats); and it is very unlikely that there is a common DNA sequence ... -Aug 1994 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Our genes aren't us!Almost without exception, biology textbooks, scientific papers, popular articles, and TV documentaries convey the impression that an organism's genes completely specify the living animal or plant. In most people's minds, the strands of DNA are analogous to computer codes that control the manufacture and disposition of proteins. Perhaps our current fascination with computers has fostered this narrow view of heredity. Do our genes really contain all the information necessary for constructing human bodies? In the April 1994 issue of Discover, J. Cohen and I. Stewart endeavor to set us straight. The arguments against the "genes-are-everything" paradigm are long and complex ...
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... Issues This Issue Sourcebook Project Sourcebook Subjects The Most Profound Discovery Of Science This is what one scientist calls Bell's Theorem. Certainly not all scientists would agree with such an absolute declaration. Since Bell's Theorem lurks in the fog-shrouded country of quantum mechanics, most biologists probably haven't even heard of it. In any event, they would probably think the discovery of the genetic code more profound. Why all the fuss over Bell's Theo-rem? In the laboratory, Bell's Theorem is associated with an admittedly spooky effect: the measurements made on one particle affect the measurements made on a second, far-removed particle. In theory, the second particle could be on the other side of the galaxy, with absolutely no physical connection between the ... -- unless you admit to spooky action-at-a -distance forces. (Some over-ly zealous think-tankers have even contemplated applying this effect to long distance, untappable, unjammable communications with submarines!) The article (referenced below) in which this apparent magic is discussed also dwells on another profundity associated with quantum mechanics: does that which is not observed exist? Einstein felt intuitively that it did; and one of his remarks on the subject led to this article's title. Unfortunately for Einstein, all recent laboratory experiments demonstrate that spooky actionat-a -distance forces do exist and that Einstein's intuition was incorrect. (Mermin, N. David; "Is the Moon There When Nobody Looks? Reality and the Quantum Theory," Physics Today ...
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... Issues Last Issue Next Issue Sourcebook Project Sourcebook Subjects Contents Archaeology Standing-stone Cluster in Eastern Massachusetts Megalithic Recycling Astronomy Planets As Sun-triggered Lasers Neptune's Arcs: Embryonic Moons? Next Let Us Consider Uranus What is It? A Black Hole, of Course! Biology Nessie Photos Not Retouched Frog Mothers Do So Care! Glitch in the Evolution of Funnelweb Spider Venom? Circadian Rhythms and Chemotherapy Genetic Code Not Universal! Geology Back to Guadeloupe Again Galapagos Younger Than Thought Libyan Desert Glass May Not Be the Product of Impacts. Geophysics Quakes and UFOs Vanishing Goo Multiple Whirlwind Patterns Psychology Mnemonism Not So Easy! Hypnotic Misrecall Chemistry & Physics Fruitfulness of Math Not An Intimation of A Transcendent Mind! The Most Profound Discovery of Science Messengers of A "new Physics" Double Nuclei At Darmstadt ...
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... been in a coma the past couple months, you have heard that the Big Bang has now been elevated from a theory to a fact. The reason for the media hullabaloo was the announcement that minute fluctuations had been detected in the cosmic microwave background. The media hype was notably chauvinistic. Some Big-Bang proponents declared that discovery was the greatest scientific advance of the century, completely ignoring the genetic code, continental drift, nuclear fission, and so on and so on. More sober scientists rejected such extravagant claims. They pointed out that independent confirmation of the fluctuations was yet to come and that, after all, the fluctuations were very small (only some 30 millionths of a K). And which of the many variations of Big Bang was going to be enthroned? Even Nature ... extreme caution, quoting H. Bondi in this regard: ". .. the data in cosmology are so likely to be wrong that I propose to ignore them." (Anonymous; "Big Bang Brouhaha," Nature, 356:731, 1992.) Comment. It is ironical that before astronomers found large-scale inhomogeneities in the cosmos (galactic clusters and superclusters, the Great Wall, etc.), the Big Bangers claimed that the very smoothness of the microwave background proved the reality of the Big Bang. The Big Bang, it seems, is one of those "politically correct" paradigms, which one criticizes at his peril. (Beichman, Arnold; "The Big Bang Censorship," Insight , p. 22, April 13, 1992. Cr. ...
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... and the discontinuous (quantized?) fossil record. (Campbell, Neil A.; "Resetting the Evolutionary Timetable," BioScience, 36:722, 1986.) Comments. When we suggest quantization in biology, two phenomena come to the fore: 1. The obvious splitting of life into well-defined states -- the species -- as defined morphologically and/or by the genetic code; and 2. The gaps in the fossil record, which imply a frequent lack of transitional forms from one species to another. As Stanley asserts repeatedly in his interview, the fossil record is actually quite good in many places, despite the long-voiced claims of the gradualists that transitional forms do not exist merely because of the deplorable state of the fossil record. In physics the ... phenomena would be: (1 ) The chemical elements and their isotopes (or an atom's energy levels); and (2 ) The lack of transitional forms. Straining the analogy still further, the evolution of one species into another simply means that life-as-a -whole moves from one quantized state to another. There need be no transitional forms, just as there are none when elements are transmuted or galaxies change redshifts (? ). Atomic physicists, long since mystical about this whole business, no longer try to explain what happens during a quantum transition. The only observables are the quantum states -- or species, if you will. Is life no more than a Table of Isotopes, defined once and forever by eerie quantum selection rules? Reference. Many ...
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... thinkers and non-thinkers. (Morowitz, Harold J.; "Do Bacteria Think?" Psychology Today, 15:10, February 1981.) Comment. This ancient controversy about determinism has been revived as: (1 ) Simple life forms have been found to be not-so-simple; (2 ) All life seems unified by a single (or small number of) genetic codes; and (3 ) "Higher" life forms seem more and more to be just composites of simpler, cooperating biological entities. From Science Frontiers #15, Spring 1981 . 1981-2000 William R. Corliss ...
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... Science Frontiers ONLINE No. 46: Jul-Aug 1986 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects The Music Of The Genes "S . Ohno has cracked a new genetic code. The 58-year-old geneticist doesn't have the whole thing worked out yet, but when he sets the genes to music -- or music to genes -- some strange and wonderful things occur. To wit: "The SARC oncogene, a malignant gene first discovered in chickens, causes cancer in humans as well. When Ohno translated the gene into music, it sounded very much like Chopin's Funeral March. "An enzyme called phosphoglycerate kinase, which breaks down glucose, or sugar, in the body revealed itself to Ohno ... a lullaby." Seeing this item is from a newspaper, it was nearly consigned to the wastebasket. But wait a moment, Susumo Ohno is a Distinguished Scientist at the Beckman Research Institute of the City of Hope National Medical Center, Duarte, CA. Could there be something to it? Reading further; we find that Ohno believes that the structure of music seems to parallel that of the genes. He translates genes into music by assigning notes according to molecular weights. His ultimate goal is the discovery of some basic pattern (melody?) that governs all life. (Anonymous; "Scientist Tunes in to Gene Compositions," San Jose Mercury News, p. E1, May 13, 1986. Cr. P. Bartindale.) Comment. Not too long ago the motions ...
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