... Science Frontiers ONLINE No. 22: Jul-Aug 1982 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects The Nomads Within Us It was originally believed that human chromosomes were fixed at conception and all subsequent organic development proceeded from the instructions encoded on them. Biologists have recently discovered that genes grasshopper about, constantly modifying genetic instructions -- at least that's the current thinking. Additional modification of genetic instructions seems to be accomplished by entities called "nomads" or "mobile dispersed genetic elements." One type of nomad is a simple ring of DNA called a plasmid. Plasmids seem to be identical to a kind of virus called a retrovirus, which can penetrate into cells and tamper with gene expression; that is, the way genetic instructions are interpreted. Plasmids have been discovered in maize, fruit flies, bacteria, and, now, humans -- and healthy people at that. No one is quite sure what these plasmids do. Even though they look like retroviruses, they may not be associated with illness, but rather help organisms adapt to changing environments. But no one really knows. (Anonymous; "Human Wandering Genes Can Live on Their Own," New Scientist, 94:18, 1982.) Comment. So, the human body is not only beset by new genetic instructions and the static introduced by invading viruses and other disease agents, but it has an indigenous population of nomads continually fiddling with our cells' genetic instructions. Our bodies seem more like Grand Central Station with trains loaded with new biological ...

... the greatest surprises of modern molecular biology has been the discovery of "split genes" in higher forms of life. In the chromosomes of lowly bacteria, genes march along one behind the other, but in more complex organisms the genes are separated by segments of genetic material that apparently have nothing to do with the manufacture of protein. Because there seems no need for these inserted jumbles of genetic information, they are characterized as "nonsense." But evolutionists insist that this nonsense must have some survival value or it wouldn't be there! Present speculation is that the nonsense segments separate mini-genes that contain the blueprints for assembling well-defined parts of proteins that possess specific functions. To illustrate, the main part of the immunoglobulin molecule has four functional parts (one for interacting with cell membranes, another that functions as a hinge, and so on). Lo and behold, the immunoglobulin gene consists of four mini-genes separated by three segments of nonsense. The suspicion is that the evolution of higher life forms has been accelerated by keeping these prefabricated, functionally oriented mini-genes apart and shuffling them as integral units. The shuffling of entire functional elements rather than smaller bits and pieces of genetic information might speed up organic evolution. (Lewin, Roger; "Why Split Genes?" New Scientist, 82:452, 1979.) From Science Frontiers #8 , Fall 1979 . 1979-2000 William R. Corliss ...

... Science Frontiers ONLINE No. 35: Sep-Oct 1984 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Caenorhabditis Elegans The creature with this formidable name is only about a millimeter long and develops from egg to adult in about 3.5 days, at which time it possesses about 1,000 somatic cells. C. elegans is a roundworm, but a famous one. Its growth has been followed on a cell-bycell basis from egg to adult. The history of each cell is known from birth to death. The fact that C.elegans is nicely transparent helps the cell-watcher. Here are some of the interesting things to be seen as cells proliferate, live, and die. First, C. elegans is bilaterally symmetrical, but the pattern of cell generation on the right differs from that on the left. Nevertheless, the creature ends up symmetrical, making one wonder where the directions for symmetry come from. Some cells are transients, dying when their jobs are done. A few doomed cells are generated only because they produce sister cells that are needed in the final animal. Such a programmed loss of cells may be a method of modifying an organism during evolution. John Sulston, one of the researchers, says, "Within the lineage you can see the fossil of its past." (Marx, Jean L.; "Caenorhabditis Elegans: Getting to Know You," Science, 225:40, 1984.) Comment. Sulston's statement reminds one of "Ontogeny recapitulates phylogeny," ...

... Science Frontiers ONLINE No. 34: Jul-Aug 1984 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Dna Even More Promiscuous It was a surprise when DNA sequences from mitochondria in yeast cells were discovered setting up shop in the nuclear genomes (i .e ., the normal genetic endowment of the cell nucleus). Now biologists find that DNA sequences in many species regularly and frequently hop from one genome to another. Genetic material from cell chloroplasts mix with that of the mitochondria and that of the normal nucleus in what seems to be a free-for-all. This genome hopping has earned DNA the adjective "promiscuous." The significance of DNA promiscuity is to be found in the general belief that the cell's mitochondria and chloroplasts were once independent biological entities that, in the course of life's development, invaded or were captured by cells and have led a symbiotic life ever since. The mitochondria and chloroplasts perform certain important functions in the cell but were thought, until now, to retain considerable genetic independence. (Lewin, Roger; "No Genome Barriers to Promiscuous DNA," Science, 224:970, 1984.) Comment. The promiscuity of DNA raises speculation that other DNA-bearing entities that invade the body, especially the viruses, may transfer their DNA to the host, and conceivably vice versa. With DNA apparently much more promiscuous than believed earlier, the role of disease in the development of life takes on a new importance. In other words, all species can potentially exchange genetic ...

... . 34: Jul-Aug 1984 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects The mind's control of bodily processes T.X . Barber has reviewed the role of the mind in the control of many physiological processes in a chapter appearing in a new book. The chapter is 58 pages long, with 176 references, making it a major contribution to the subject. To give the reader the flavor of this paper, two paragraphs are now reproduced: "The data presented in this chapter should, once and for all, topple the dualistic dichotomy between mind and body which has strongly dominated Western thought since Descartes. The meanings or ideas imbedded in words which are spoken by one person and deeply accepted by another can be communicated to the cells of the body (and to chemicals within the cells); the cells then can change their activities in order to conform to the meanings or ideas which have been transmitted to them. The believed-in (suggested) idea of being stimulated by a poison ivy-type plant, transmitted to a person who is normally hypersensitive to this type of plant, can affect specific cells (probably in the immunological and vascular systems) so that they produce the same type of dermatitis which results when the person actually is stimulated by a poison ivy-type plant. Similarly, individuals who are viewed as allergic to pollen or house dust may not manifest the allergic reaction when they believe (falsely) that they have not been exposed to the allergic substance. .. .. . "Believed ...

... " is important in controlling the progression of serious diseases. Most of the evidence linking the patient's mood with recovery from illness is anecdotal -- little wonder since mood is hard-to-measure. Some statistical evidence has recently been accumulated by S.M . Levy and R. Herber-man of the National Cancer Institute; but the situation still seems complex at best. From a study of 75 women with breast cancer, there appears to be a significant and involved relationship between age, the body's immune function, and a psychological factor called "fatigue." One clear-cut finding was that young patients facing radiation therapy and also reporting high levels of psychological fatigue were the only patients in the surveyed group showing diminished activity by the body's natural killer cells. These killer cells com-prise an important part of the defense against cancer. This biological consequence of apathy is confirmed by an-other study showing that cancer patients with "psychological distress" had better chances of recovery than those who had no "fight." (Herbert, W.; "Giving It Up -- At the Cellular Level," Science News, 124:148, 1983.) Comment. Assuming such mind-body correlations are real, how is mental attitude (supposedly some pattern of nerve signals in the brain) converted into greater or lesser populations of natural killer cells? From Science Frontiers #30, NOV-DEC 1983 . 1983-2000 William R. Corliss ...

... Science Frontiers ONLINE No. 33: May-Jun 1984 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Rubberneckia The long-standing belief that unlimited rotary motion is impossible in animals has been shattered. It was, after all, a very reasonable assumption, because necks and other appendages turn only so far before bones and muscles begin to snap. Well, it seems that inside ter-mite guts there resides a single-celled animal with a head that rotates constant-ly 30 times a minute. Since none of its membranes shear during rotation, we must infer that membranes are basically fluid structures rather than solids as supposed. The animal, called Rubberneckia, has a shaft running the full length of its body plus a motor of undetermined character. To make Rubberneckia even more bizarre, thousands of tiny, rod-like bacteria occupy long grooves on the cell's surface. Like galley slaves, the bacteria row with their flagella to keep Rubberneckia moving -- a curious symbiotic relationship. (Cooke, Robert; "A Tale to Make Your Head Spin,: Boston Globe, March 20, 1984, p. 1. Cr. P. Gunkel) From Science Frontiers #33, MAY-JUN 1984 . 1984-2000 William R. Corliss ...

... All Issues This Issue Sourcebook Project Sourcebook Subjects Mind Before Life For some years S.W . Fox, at the Institute for Molecular and Cellular Evolution, University of Miami, has been experimenting with possible precursors of life. So-called "microspheres" are hot items in Coral Gables these days. Fox and his colleagues make microspheres by preparing a heated stew of various amino acids. These amino acids form long polymer chains spontaneously. Then, when water is added and the mixture reheated (or processed in some other way), the polymers organize themselves, again spontaneously, into spheres a few microns in diameter. Each sphere consists of a two-layer membrane with residual material trapped inside. Although thicker, the microsphere membrane is very similar to the lipid bi-layer enclosing normal living cells. The relatively stable microspheres could, in theory, have formed sheltered environments for the evolution of the more complicated parts of living cells. The microspheres absorb sunlight and, with the addition of this energy, display some of the electrical characteristics of biological neurons, like those in the brain. The implication is that some components of "mind" may have existed in the very earliest life forms. (Peterson, Ivars; "Microsphere Excitement," Science News, 125:408, 1984.) Comment. Two comments here: First, the word "spontaneous" is customarily employed when describing how atoms unite to form molecules and molecules combine into polymers, which then gather into microspheres. The word "spontaneous" seems to imply chance is operating rather than design. Actually, atoms ...

... Science Frontiers ONLINE No. 37: Jan-Feb 1985 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects The genome's responses to challenges The genome is an organism's genetic endowment. It contains instructions for the organism's growth and development, but it is not like a rigid, uncompromising computer program. Rather, the genome: ". .. is a highly sensitive organ of the cell that monitors genomic activities and corrects common errors, senses unusual and unexpected events, and responds to them, often by restructuring the genome. We know about the components of genomes that could be made available for such restructuring. We know nothing, however, about how the cell senses danger and instigates responses to it that often are truly remarkable." Thus Barbara McClintock ends the paper she delivered in Stockholm when she received a Nobel Prize in 1983. Most of McClintock's paper reviews her pioneering work with the corn genome, but she adds some examples of other genomic responses to external stresses. One such stress is applied to an oak tree when a wasp lays its egg in a leaf. The stress causes the oak genome to reprogram itself and construct a wholly new and unplanned plant structure to house and feed the developing insect. Some of these structures (galls) are very elaborate and are precisely tailored to each different wasp species. From such examples, it is apparent that the genome of an organism somehow perceives stresses and reacts to them -- often in completely unanticipated ways. The stresses may be mechanical, thermal ...

... datable volcanic ash. The new dates for this civilization are 600-1 ,500 BC, putting it about 1,000 years ahead of Maya and Inca achievements. The "digs" show further that this culture was frequently beset by devastating outbursts of volcanic activity, which often rendered large areas of land uninhabitable. Rather than suppressing this remarkable culture, Donald Lathrap, a University of Illinois archeologist, says: "Those disasters pushed people from the region and led to upward leaps in social evolution..." (Anonymous; "Key to a Vanished Empire," San Francisco Chronicle, June 14, 1984. Cr. J. Covey.) Comment. The reaction of this early society of advanced organisms to environmental stress seems a perfect introduction to several items that follow on how cells and other species respond to stresses from without. From Science Frontiers #37, JAN-FEB 1985 . 1985-2000 William R. Corliss ...

... Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Killer Fungi Cast Sticky Nets Your garden soil likely contains nematodes (popularly called eelworms) that will gnaw away at your crops. Nematodes are about a millimeter long and very active, thrashing through the soil like fish through water. Their numbers are kept in check by a surprisingly sophisticated fungus which thrives on them. If nematodes are around (not otherwise), the fungus sets out two kinds of traps. The first is the sticky net made of threads sent out by the fungus. Any nematode that brushes against these sticky strands is held while the fungus rams special feeding pegs into it. The second kind of trap is even more marvelous. It is an array of rings, each consisting of three unique cells that are sensitive to touch. Attracted by alluring chemicals secreted by the fungus, the nematodes probe around the rings. In a tenth of a second after they are touched, the fungus rings contract around the interloping nematodes. Again the nematode is doomed as the terrible feeding pegs penetrate its body. Another chemical is then released by the fungus to keep other fungi away from its kill. (Simons, Paul; "The World of the Killer Fungi," New Scientist, 20, March 1, 1984.) Comment. Does anyone really believe that even the "simplest" form of life is really simple? From Science Frontiers #33, MAY-JUN 1984 . 1984-2000 William R. Corliss ...

... Science Frontiers ONLINE No. 49: Jan-Feb 1987 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Million-cell memories?Brain researchers have long believed that simple memories were stored as "traces" in chains of brain cells. However, E.R . John and his colleagues have confounded such thinking. They have prepared metabolic memory maps of cats' brains using carbon-tagging. In this way, they discern which parts of the brains have been activated during the recall of an element of memory. Such experimentation has demonstrated that huge numbers of brain cells actively participate in the recall of a simple thought. John stated, "I thought we'd find maybe 20,000 to 40,000 cells involved in the learned memory....The shock was that it was so easy to see wide-spread metabolic change....The number of brain cells [between 5 million and 100 million] involved in the memory for a simple learned discrimination made up about one-tenth of the whole brain." The findings of John et al are hotly contested by some brain researchers. One obvious conflict is that if up to 100 million brain cells are involved in storing just one simple memory, the brain will quickly use up all available cells. It must be that individual brain cells can participate in the storage of many different memories. The conventional mem-ory-trace theory would have to be replaced by a new type of memory architecture. (Bower, Bruce; "Million-Cell ...

... Science Frontiers ONLINE No. 48: Nov-Dec 1986 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Geocorrosion?In studying the minute electrochemical cells responsible for metal corrosion, J.G . Bellingham and M.L .A . MacVicar, at MIT, discovered a remarkable effect: "One interesting and surprising property of electrochemical cells was discovered by accident. Normally, the magnetometer scans each cell as the cell moves horizontally beneath the magnetometer. During one run, the researchers left the cell in a single position for a long time while the magnetometer was still on. After 20 minutes or so, the magnetic field strength began to drop. 'It was very dramatic to watch this field collapse,' says MacVicar. After about a minute at zero, the magnetic field grew larger again but in the opposite direction." These reversals occurred over and over again at regular intervals. (Peterson, I.; "Tracing Corrosion's Magnetic Field," Science News, 130:132, 1986.) Comment. The self-reversal of magnetic specimens has been observed before under some conditions, but here is a periodic reversal of an electrochemical system. Why place it under the heading of Geology? Because the earth's field seems to reverse on a fairly regular basis. Catastrophists have invoked as teroid or cometary collions to account for these flip-flops, but it might be that the earth contains giant electrochemical cells that spontaneously reverse on a million-year timescale rather than minutes. We know the earth' ...

... Science Frontiers ONLINE No. 47: Sep-Oct 1986 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Heretical Evolutionary Theory "Over the past 15 years, away from the limelight of mainstream evolutionary argument, cell biologists have been debating a concept that is fundamental to our understanding of how cells evolved. It is the proposal that some of the structures that are found in the larger cells of animals, plants and fungi (eukaryotic cells) are the descendants of simpler bacteria-like organisms (prokaryotic cells) that had at some stage entered into an intracellular existence, or endosymbiosis. The idea is not a new one, but only in the light of modern experimental evidence has it become acceptable to many biologists. If the hypothesis is correct, then virtually all the major groups of familiar organisms originated 'suddenly' through endosymbiotic associations." Following this lead paragraph, with its paradigm-shaking final sentence, are three pages summarizing the biological evidence favoring evolution by endosymbiosis. (Kite, Geoffrey; "Evolution by Symbiosis; The Inside Story," New Scientist, p. 50, July 3, 1986.) Comment. We cannot possibly do justice to this exciting idea of evolution forced by the uniting of different organisms in the limited format of Science Frontiers. Instead, we encourage readers to purchase a new book by L. Margulis and D. Sagan (son of Carl Sagan and L. Margulis) entitled Micro Cosmos. In passing, we must also remark on the obvious relationship of endosymbiosis to F. Hoyle's ...

... Science Frontiers ONLINE No. 50: Mar-Apr 1987 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects How Cancers Fight Chemotherapy How do cancer cells develop resistance to lethal chemicals? The clues seem to reside in extrachromosomal DNA that carries drug-resistance-conferring genes from one cancer cell to another. Cancer cells dying from chemotherapy may, for example, cast off extrachromosomal DNA that carries information on how to combat the chemicals. Other factors may also be at work, but basically we have only suspicions. (Silberner, Joanne; "Resisting Cancer Chemotherapy," Science News, 131:12, 1987.) Comment. Insects and other organisms also acquire resistance to chemical poisons. Does extrachromosomal DNA play roles in these instances, too? Can Information coded in extrachromosomal DNA be passed from one species to another, say, via insect bites? From Science Frontiers #50, MAR-APR 1987 . 1987-2000 William R. Corliss ...

... Muller and D.E . Morris review the evidence tying geomagnetic reversals to the impacts of large bodies with the earth: the tektites and microtektites; the climate changes; the biological extinctions, etc. Then they propose a physical mechanism for geomagnetic reversals: "The impact of a large extraterrestrial object on the Earth can produce a geomagnetic reversal through the following mechanism: dust from the impact crater and soot from fires trigger a climate change and the beginning of a little ice age. The redistribution of water near the equator to ice at high latitudes alters the rotation rate of the crust and mantle of the Earth. If the sea-level change is sufficiently large ( 10 meters) and rapid (in a few hundred years), then the velocity shear in the liquid core disrupts the convective cells that drive the dynamo. The new convective cells that subsequently form distort and tangle the previous field, reducing the dipole component near to zero while increasing the energy in multipole components. Eventually a dipole is rebuilt by dynamo action, and the event is seen either as a geomagnetic reversal or as an excursion." (Muller, Richard A., and Morris, Donald E.; "Geomagnetic Reversals from Impacts on the Earth," Geophysical Research Letters, 13:1177, 1986.) Comment. That the earth's field is generated by internal dynamo action is still a theory, although a widely accepted one. From Science Frontiers #49, JAN-FEB 1987 . 1987-2000 William R. Corliss ...

... ONLINE No. 47: Sep-Oct 1986 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Unpredictable Things Simple spherical pendulums are fixtures of physics labs, to say nothing of grandfather clocks. It is now widely recognized that pendulums can behave chaotically; that is, unpredictably. As the pendulum bob swings farther away from its rest position, the restoring force becomes nonlinear; i.e ., not proportional to the displacement. At some combination of displacement and driving frequency, a region of chaos may develop, in which theory is powerless to tell what is going to happen next. "It is not just the behavior of pendulums that has sprung this surprise. Systems as diverse as simple electrical circuits, dynamos, lasers, chemical reactions and heart cells behave in an analogous way and the implications extend far beyond these examples -- to matters such as weather forecasting, populations of biological species, physiological and psychiatric medicine, economic forecasting and perhaps the evolution of society." (Tritton, David; "Chaos in the Swing of a Pendulum," New Scientist, p. 37, July 24, 1986.) Comment. Some of the anomalies we record may be the consequence of simple systems gone wild. Chaotic motions of some asteroids and at least one solar system moon are already suspected. Imagine what might happen in much more complex systems, such as biological evolution (hopeful monsters?), brain development (idiot savants?), etc. From Science Frontiers #47, SEP-OCT 1986 . 1986-2000 William ...

... Science Frontiers ONLINE No. 58: Jul-Aug 1988 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Bacteria One dictionary's definition: "Widely distributed group of microscopic, one-celled vegetable organisms..." As a matter of fact, the nearly universal image of a bacterium is that of a simple, single-cell organism. But: "That view is now being challenged. Investigators are finding that in many ways an individual bacterium is more analogous to a component cell of a multicellular organism than it is to a free-living, autonomous organism. Bacteria form complex communities, hunt prey in groups and secrete chemical trails for the directed movement of thousands of individuals." J.A . Shapiro, author of the preceding quote, attributes the simplistic picture of bacteria to medical bacteriology, in which disease-causing bacteria are classically identified by isolating single cells, growing cultures from them, and then showing that they cause the disease in question. In the microscopic real world, bacteria virtually always live in colonies, which possess collective properties quite different and much more impressive than those of the single-cell-in-a -dish! That old human urge for reductionism has led us astray again. Shapiro seeks to remove the blinders of reductionism in a wonderful article in the June, 1988, issue of Scientific Amer can . We have room here to mention only the Myxobacteria, many of which never exist as single cells in nature. Even those that do are "social" in the sense that ...

... Online All Issues This Issue Sourcebook Project Sourcebook Subjects Fractals, fractals everywhere Anyone who follows the popular scientific literature knows that fractals are now "in." Commonly employed to "explain" patterns in nature, fractals are, from a simplistic viewpoint, mathematical ways to predict the development of a growing structure, be it a crystalline mass, a plant, or the universe-as-a -whole. Yes, the universe-as-a -whole, the clouds of stars and clusters of galaxies, may be mimicked by cellular automata (i .e ., fractals). Imagine the universe as a cubical lattice, and start in one corner, adding one layer of cubes after another. Galaxy distribution could be simulated by using a rule telling us which of the added cubical cells had galaxies in them and which did not. "The rule actually used supposes that the question whether each point in a newly added layer will (or will not) be occupied by a galaxy is mostly determined by the occupancy of the five nearest neighbors in the previous layer, but for good measure, there is a random variable to introduce an element of white noise to the system. To make the process a little more interesting, the determination whether a new site is occupied depends on whether a number characteristic of that site, and calculated by simple arithmetic from the corresponding number for the five nearest neighbors in the preceeding layer, exceeds an arbitrarily chosen number." Comparing this fractal simulation with the observed universe is startling. The agreement is "spectacularly successful." (Maddox, ...

... increase with time. Do formative or guiding principles exist that science does not take into account? The two articles have very different answers. The creative cosmos. "Most people accept without question that the physical world is coherent and harmonious. Yet according to the traditional scientific picture, the Universe is just a random collection of particles with blind forces acting upon them. There is, then a deep mystery as to how a seemingly directionless assembly of passive entities conspire to produce the elaborate structure and complex organisation found in nature." The author of this introductory paragraph, P. Davies, asks, as we all do, "What is the origin of this creative power?" In groping for an answer, he presents first a common example of "blind" organization: the hexagonal convection cells in a pan of heated water. Using for a stepping stone the cooperative action of atoms in a laser, he leaps to the development of an embryo from a single strand of DNA! All such systems are "open"; that is, energy can flow in and out. They are also nonlinear, which means that chaotic, unpredictable action may occur. Davies implies that such action can be "creative," almost as if they possessed free will! His final example is that of the network with large numbers of interacting sites or nodes. With random inputs, large networks do exhibit self-organization. Network theory is now very popular in the field of artificial intelligence. (Remember the computer Hal in 2001?) Davies's conclusion: ". .. Neo ...

... Science Frontiers ONLINE No. 51: May-Jun 1987 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects The Mite Pockets Of Lizards "Many lizards are infested by chig gers, the larvae of trombiculid mites, which feed on tissue fluid and cell debris. Surprisingly, lizards seem to go out of their way to attract the chiggers -- they have special mite pockets that provide a protected, warm and humid site. In many cases, the skin of the lizard also has smaller scales than normal and a good blood supply in the pocket, which enables the parasites to feed more readily." There does not seem to be any advantage to the lizards providing plush accommodations for the chiggers. The chiggers can wreak havoc on their hosts in the form of skin lesions, allergic reactions, secondary infections, and the transmission of diseases. Nevertheless, some 150 species in 5 distinct lizard families possess mite pockets, which are often located in different places in different lizard species. Apparently, the mite pockets evolved separately several times. But why? (Benton, Michael J.; "The Mite Pockets of Lizards," Nature, 325:391, 1987.) Comment. Why haven't the lizards evolved thicker skin or some sort of chemical defense instead of reducing their fitness with mite pockets? Or, are other factors operating? From Science Frontiers #51, MAY-JUN 1987 . 1987-2000 William R. Corliss ...

... Science Frontiers ONLINE No. 67: Jan-Feb 1990 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Dna On Cell Surfaces DNA attached to a cell's surface? Such a notion was shocking to scientific orthodoxy in the 1970s. At that time, observations of the phenomenon were rejected. Even worse, funding to continue the work was not forthcoming. Happily, other researchers have later stumbled onto cell-surface DNA; and this startling phenomenon has been rescued from conformity's wastebasket. Now that cell-surface DNA can be talked about, we can wonder aloud where it comes from and what its significance is. First, this out-of-place DNA -- thought to amount to about 1% of a cell's total DNA -- could come from either inside the cell itself or from blood-borne cellular debris. There is considerable argument on this point. Second, this cell-surface DNA does not appear to undergo replication nor does it perform any gentic coding function. Speculation is that it may somehow be involved in the immunological response of the body; for its position on the cell surface is ideal for such a role. Some researchers think that cell-surface DNA may aid in the drug treatment of T-cell lymphoma, a type of cancer. On the other side of the coin, it may mask those molecules on tumor cells that provoke immune responses. Such divergence of opinion indicates how much there is to learn here. (Wickelgren, Ingrid; "DNA's Extended ...

... Science Frontiers ONLINE No. 69: May-Jun 1990 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Spontaneous order, evolution, and life In our thinking, one of the most remarkable articles ever to appear in Science bears the above title. Most re markable of all is the use of the word "spontaneous" without philosophical comment. The stimuli for the research described are such observations as: (1 ) life exists; (2 ) life evolves; (3 ) the fossil record displays stasis, extinctions, and great gaps between phyla and lesser classifications; and (4 ) disordered molecules move smoothly and surely into the order manifest in the living cell. The question asked in the article is whether science has missed something in its description of the origin and development of life. Just what makes molecules coalesce into cells and humans? The answer given is: spontaneous self-organization ! In other words, there is no guiding external force. Molecules do this spontaneously. There are even computer models being developed, based on a branch of mathematics called "dynamical systems," that describe how this all happens - spontaneously, of course. (Waldrop, M. Mitchell; "Spontaneous Order, Evolution, and Life," Science, 247:1543, 1990.) Comment. When water molecules spontaneously cluster together to form a snowflake, with all its symmetry and order, science explains the process in terms of the properties of water molecules. The same must be true when molecules merge to form life forms. But ...

... Science Frontiers ONLINE No. 76: Jul-Aug 1991 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Psi Effects In The Sacrifice Of Marine Algae It is safe to say that mainstream science will categorically reject the results of the experiments reported below. The reason is simple: no known mechanism exists for ESP -- in this instance, the anomalous transfer of information between isolated life forms. Experimental setup for measuring the activity of marine algae. Two scientists at the University of Delaware have designed an experiment that measures the activity of marine algae in a seawater culture. By passing a laser beam through the culture and thence to a photomultiplier tube, they can, utilizing the Doppler shift, measure the collective activity of the cells. (See figure.) Various experiments were run by the Delaware researchers, but their second series in particular seems worth reporting. "A second series of experiments used the sacrifice of clones as a distant stimulus. The data appear to show that the marine alga Tetraselmis suecica reacts dramatically to the sacrifice of cells in a physically isolated aliquot of the same culture if the experimenters are aware of the moment of sacrifice, and excited by the novelty of the experiment. In sharp contrast, only marginally significant results were obtained when the same experiment was run entirely automatically, with the time of the sacrifice defined by random number selection, and the experiment activated by computer command in an empty laboratory." (Pleass, C.M ., and Dey, N. Dean; "Conditions That Appear to Favor Extrasensory ...

... a few other mammals and marsupials evolved foregut fermentation. It is hardly a primitive development! Aside from the smell of fermenting vegetable matter, the hoatzin is a rather remarkable animal - more advanced and well-adapted to its environment than previously thought. Grajal et al remark on all the advantages that foregut fermentation confer on the hoatzin and how remarkable it is that this digestive process can be accomplished in such a small volume (cows have huge stomachs). How did the hoatzin hit upon this mechanism before the mammals did? Why didn't other birds "adopt" it? Grajal et al speculate about this hoatzin advance: "Their highly specialized digestive strategy may have arisen from an ancestral nonobligate folivore because of an evolutionary trade-off between detoxification of plant chemical defenses and enhanced use of cell wall as a nutritional resource." (Grajal, Alejandro, et al; "Foregut Fermentation in the Hoatzin, a Neotropical Leaf-Eating Bird," Science, 245:1236, 1989.) Comment. The rather murky quotation above is only speculative. Leaves are abundant in the tropics, and it is fair to ask why other birds did not develop foregut fermentation. From Science Frontiers #66, NOV-DEC 1989 . 1989-2000 William R. Corliss ...