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No. 40: Jul-Aug 1985

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Circadian Rhythms And Chemotherapy

The toxicities of many commonly used anticancer drugs depend upon when they are administered during the day. This phenomenon occurs in humans and other animals. The effect is not trivial but "profound."

(Hrushesky, W.J.M.; "Circadian Timing of Chemotherapy," Science, 228:73, 1985.)

Comment. This "profound" effect should, by extrapolation, also apply to drug potency, the workings of the immune system, and all biochemical reactions. The location of and reason for the circadian clock are matters of conjecture.

From Science Frontiers #40, JUL-AUG 1985. © 1985-2000 William R. Corliss

Science Frontiers Sourcebook Project Reviewed in:

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  • "Before opening the book, I set certain standards that a volume which treads into dangerous grounds grounds like this must meet. The author scrupulously met, or even exceeded those standards. Each phenomenon is exhaustively documented, with references to scientific journals [..] and extensive quotations" -- "Book Review: The moon and planets: a catalog of astronomical anomalies", The Sourcebook Project, 1985., Corliss, W. R., Journal of the Royal Astronomical Society of Canada>, Vol. 81, no. 1 (1987), p. 24., 02/1987