90 results found.
... Science Frontiers ONLINE No. 115: Jan-Feb 1998 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Genes vs. memes Vital to the concept of "gene wars" (mentioned in SF#114) is the assumption that our destiny is controlled by "selfish genes" (or "selfish DNA"). The idea that evolution works only at the gene level has been championed by R. Dawkins, and today it dominates much evolution philosophy. However, this "genetic imperialism" is now being challenged by some scientists who insist that culture also affects an organism's evolution, be it a human or an insect. In fact, it was Dawkins himself who first proposed the term "meme" for the cultural counterpart of the gene. A meme, in other words, is an "element" of culture that can be passed along to progeny by imitation and/or cultural pressures. In reductionist thinking, environmental challenges are met by gene mutations plus natural selection. In meme theory, the same challenges are confronted by cultural changes (meme "mutation") plus natural selection. The meme approach is holistic rather than reductionist and is appealing because it allows us some control over our destiny. There are several phenomena in which some scientists profess to see memes overpowering the genes: Generations of female infanticide have led to more male births than female births. In dairy-farming societies, 90% of the population has the enzyme lactase that allows individuals to digest cows' milk. In other societies, 80% ...
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... Science Frontiers ONLINE No. 114: Nov-Dec 1997 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Gene Wars In past issues, we have mentioned: Sperm wars. Where an animal's sperm are polymorphic; some of which attack alien sperm, some dash directly to the eggs, etc. (SF#78) Selfish DNA. Where animals are merely mechanisms by which DNA perpetuates itself and expands its domain. In other words, DNA calls the shots -- not us! (SF#11) Now we learn about "gene wars." As is well known, genes are thought to control much of what goes on in a living organism. But are they only carriers of hereditary information? Not according to a long, very technical paper by L.D . Hurst et al. It seems that, like selfish DNA, genes have their own agendas. The insidiousness of this is seen in the first sentence of the paper's abstract: "Self-promoting elements (also called ultraselfish genes, selfish genes, or selfish genetic elements) are vertically transmitted genetic entities that manipulate their "host" [as in "us'] so as to promote their own spread, usually at a cost to other genes within the genome." You may not sense it, but your genes are struggling with each other, and you and/or your progeny will carry out the dictates of the victors of the "gene wars." (Hurst, Laurence D., et al; " ...
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... Science Frontiers ONLINE No. 139: Jan-Feb 2002 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects How The Genome's Message Can Be Altered Our genomes (complements of genes) can no longer be called sets of instructions like those in a computer program. Demonstrating the veracity of this statement are the following three quotations. Increasingly, a picture of interactivity and multifunctionality among genes is emerging that precludes such a simple one-to-one mapping. Furthermore, the genome can exhibit considerable flexibility to adapt when the expression of a particular gene fails, and the interpretation of a mutant phenotype [life form] is also less trivial than it may seen. "Not only are behavioural phenotypes very sensitive to non-genetic influences," writes [R .] Greenspan, "but also the highly interconnected network of the nervous system sets up an additional layer of complexity between the gene and the realization of the phenotype." (Ref. 1) Many genes code for multiple variants of the same protein. And many proteins are modified by adding sugar molecules, which play a big role in determining where proteins go and what they do. What's more, different proteins can join together to carry out completely new functions. (Ref. 2) A group of French biologists, led by Francois Jacob and Jacques Monod showed that the gene's boundaries are fuzzier than had been thought and that genes are not restricted to chromosomes. Recently, biologists have found genes within genes, overlapping genes, and DNA sequences that ...
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... Science Frontiers ONLINE No. 46: Jul-Aug 1986 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects The Music Of The Genes "S . Ohno has cracked a new genetic code. The 58-year-old geneticist doesn't have the whole thing worked out yet, but when he sets the genes to music -- or music to genes -- some strange and wonderful things occur. To wit: "The SARC oncogene, a malignant gene first discovered in chickens, causes cancer in humans as well. When Ohno translated the gene into music, it sounded very much like Chopin's Funeral March. "An enzyme called phosphoglycerate kinase, which breaks down glucose, or sugar, in the body revealed itself to Ohno as a lullaby." Seeing this item is from a newspaper, it was nearly consigned to the wastebasket. But wait a moment, Susumo Ohno is a Distinguished Scientist at the Beckman Research Institute of the City of Hope National Medical Center, Duarte, CA. Could there be something to it? Reading further; we find that Ohno believes that the structure of music seems to parallel that of the genes. He translates genes into music by assigning notes according to molecular weights. His ultimate goal is the discovery of some basic pattern (melody?) that governs all life. (Anonymous; "Scientist Tunes in to Gene Compositions," San Jose Mercury News, p. E1, May 13, 1986. Cr. P. Bartindale.) Comment. Not too long ago the ...
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... Science Frontiers ONLINE No. 94: Jul-Aug 1994 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Our genes aren't us!Almost without exception, biology textbooks, scientific papers, popular articles, and TV documentaries convey the impression that an organism's genes completely specify the living animal or plant. In most people's minds, the strands of DNA are analogous to computer codes that control the manufacture and disposition of proteins. Perhaps our current fascination with computers has fostered this narrow view of heredity. Do our genes really contain all the information necessary for constructing human bodies? In the April 1994 issue of Discover, J. Cohen and I. Stewart endeavor to set us straight. The arguments against the "genes-are-everything" paradigm are long and complex, but Cohen and Stewart also provide some simple, possibly simplistic observations supporting a much broader view of genetics. Mammalian DNA contains fewer bases than amphibian DNA, even though mammals are considered more complex and "advanced." The implication is that "DNA-as-a -message" must be a flawed metaphor. Wings have been invented at least four times by divergent classes (pterosaurs, insects, birds, bats); and it is very unlikely that there is a common DNA sequence that specifies how to manufacture a wing. The connections between the nerve cells comprising the human brain represent much more information than can possibly be encoded in human DNA. A caterpillar has the same DNA as the butterfly it eventually becomes. Ergo, something ...
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... Science Frontiers ONLINE No. 128: MAR-APR 2000 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects The Consciousness Gene We humans assume that our consciousness is something more than just the sum total of all our senses, as integrated by our brains. In other words, consciousness is something "special" that makes us more than automatons. Other animals may be automatons, but not us! D. Jones speculates in Nature that if consciousness is a definite, inheritable characteristic, it must have had survival value for it to have evolved. It then follows that consciousness must be en-coded somewhere in our genes. Only a single gene may be enough, for consciousness seems to be an uncomplicated phenomenon. Why? Because just a few simple molecules, such as those found in anesthetics, can disable it completely without affecting other bodily functions. Eventually, Jones continues, the gene (or small number of genes) responsible for consciousness will be identified. Then, we can determine for certain if any of the lower animals are also conscious. We think chimps and dolphins might be, but we're not really sure until we see if they have the necessary genes. In fact, the old-time behaviorists could be right, and all the other animals really are merely automatons. That would definitely make us "special"! Once we have the consciousness genes in our labs, we can introduce them into those other species, such as Rover and Kitty, upon whom we would like to confer the boon of consciousness ...
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... Science Frontiers ONLINE No. 24: Nov-Dec 1982 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Mice Transmit Human Gene Sequences To Their Progeny Viruses habitually subvert the manufacturing facilities of host cells so that they turn out viruses instead of material useful to the host. Stewart and his col-leagues injected fertilized mouse eggs with human beta-globin gene sequences. One of the resulting adult mice carried the human gene sequence intact; one of the others carried at least part of the sequence. More significantly, the latter mouse transmitted the human gene sequence to its progeny in a Mendelian ratio. (Stewart, Timothy A., et al; "Human Beta-Globin Gene Sequences Injected into Mouse Eggs, Retained in Adults, and Transmitted to Progeny," Science, 217:1046, 1982.) Comment. Animal cells are therefore not too fastidious about what they manufacture and what is transmitted to progeny. The unanswered questions are: How far can this proxy replication and transmission of genes go; and, most important, can it occur in nature to a degree sufficient to contribute to the evolution of new species? From Science Frontiers #24, NOV-DEC 1982 . 1982-2000 William R. Corliss ...
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... Science Frontiers ONLINE No. 131: SEP-OCT 2000 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Oh, The Complexity of it All!The headlines say that the human genome has been charted and further imply that we now can read life's total blueprint. Closer study of the announcement reveals that there still remain unreadable snippets of the genome here and there. In fact, the total number of human genes is still in doubt: maybe 30,000, some say 120,000. This wide range of uncertainty does not inspire belief in the accurate readability of this biological blueprint at the present time. Usually left unsaid is the fact that the present blueprint covers only 2-3 % of the territory. That's right, 97-98% of the human genome isn't mapped at all. This uncharted territory is assumed to be "junk" or "nonsense" DNA that plays no role in heredity. Want to bet that this assumption is correct? And don't forget that genes jump around. The genome is really a moving target. Genes also work in concert. It is not one gene coding for one protein, which then has a singular role in creating an operational human being. For example, some 5,692 genes are active in breast-cancer cells. Genes may also have multiple roles. Our present blueprint of the human genome does not display all the mobility and complex interrelationships of the genes. We do know that genes are the blue-prints for the ...
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... Science Frontiers ONLINE No. 108: Nov-Dec 1996 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Those selfish genes may also be intelligent!R. Dawkins has proposed that we humans and other organisms are merely lumbering life-support systems for our genes. In this view, genomes are the masters, controlling our evolution and behavior to ensure their own survival and multiplication. In short, our genes are "selfish." J. Shapiro, at the University of Chicago, has gone a step further and ascribed still another human attribute to genomes. "Genomes function as true intelligent systems, which can be readjusted when conditions require. We still lack testable theories to explain how this can be done. ( Genetica , 84:4 , 1991)" Perhaps we see evidence of this "intelligence" of genes when bacteria and other microorganisms rapidly accommodate to environmental challenges, as in the application of new antibiotics. In this context, read below about the fast-evolving cichlid fishes of Lake Victoria. These fish must have macho genes! From Science Frontiers #108, NOV-DEC 1996 . 1996-2000 William R. Corliss ...
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... Science Frontiers ONLINE No. 47: Sep-Oct 1986 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Brain architecture: beyond genes "The human brain probably contains more than 1014 synapses, and there are simply not enough genes to account for this complexity." .. .. "Neuroscientists at a recent meeting highlighted how extragenetic factors -- including neuronal activity, contact with other cells, radiation, and chemical factors -- influence brain circuitry, especially during development." In computer terms, our brains are constantly reprogramming themselves in response to internal and external forces. (Barnes, Deborah M.; "Brain Architecture: Beyond Genes," Science, 233: 155, 1986.) Comment. Musing in a Lamarckian way, can the brain, as reprogrammed by external influences, ever feed back information to the genes? From Science Frontiers #47, SEP-OCT 1986 . 1986-2000 William R. Corliss ...
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... Science Frontiers ONLINE No. 8: Fall 1979 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects The Importance Of Nonsense One of the greatest surprises of modern molecular biology has been the discovery of "split genes" in higher forms of life. In the chromosomes of lowly bacteria, genes march along one behind the other, but in more complex organisms the genes are separated by segments of genetic material that apparently have nothing to do with the manufacture of protein. Because there seems no need for these inserted jumbles of genetic information, they are characterized as "nonsense." But evolutionists insist that this nonsense must have some survival value or it wouldn't be there! Present speculation is that the nonsense segments separate mini-genes that contain the blueprints for assembling well-defined parts of proteins that possess specific functions. To illustrate, the main part of the immunoglobulin molecule has four functional parts (one for interacting with cell membranes, another that functions as a hinge, and so on). Lo and behold, the immunoglobulin gene consists of four mini-genes separated by three segments of nonsense. The suspicion is that the evolution of higher life forms has been accelerated by keeping these prefabricated, functionally oriented mini-genes apart and shuffling them as integral units. The shuffling of entire functional elements rather than smaller bits and pieces of genetic information might speed up organic evolution. (Lewin, Roger; "Why Split Genes?" New Scientist, 82:452, 1979.) From Science Frontiers #8 , Fall 1979 . ...
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... Science Frontiers ONLINE No. 135: MAY-JUN 2001 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Where Is The Maestro?As we learn more and more about the gene complements of our planet's multitudinous life forms, the more it seems that the vaunted genome may not incorporate all of the information necessary to construct a living organism. Despite assurances to the contrary, we must ask if we really know the whole story. These doubts manifest themselves as we see that creatures that are very much alike genetically may be radically different morphologically. In this vein, C. Ventner asserts that all higher vertebrates have roughly the same genes. The animals that result from these re-markedly similar genomes depend upon when specific genes are turned on and off. Ventner says, "We have the same number of genes as cats and dogs, but differently regulated." The genes themselves are supposed to be simply protein factories. Somehow, they are turned on and off (" expressing" themselves) in just the right sequences to help build the target animal. In a far-stretched analogy, the genes are the instruments in an orchestra and the proteins they produce are the notes in a symphony. But where are the symphony's score and its conductor? Very similar orchestras, it seems, can play radically different symphonies given different scores as interpreted by a maestro. Each living thing is likewise a symphony of proteins, each played by the genome at just the right time. But just where are the score -- ...
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... Science Frontiers ONLINE No. 117: May-June 1998 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects The Evolution Of Computers So, you thought this item was going to be about advances in chips, modems, and related hardware? It's not about software either. It's about bioware. The title of a recent article in Science began with: "Genomic Cis-Regulatory Logic." That's obscure enough to make you move on to the next article, particularly when you see that sea urchins are involved. But buried in all the technical jargon is a profound discovery: The genes of all living things, from sea urchins to humans, are in reality systems consisting of thousands of simple computational devices. Very, very briefly, the regulatory regions for animal genes, are termed "promoters." Promoters typically consist of a few hundred to several thousand bases of DNA. In the work of Yuh et al, the article's authors, these promoters are seen to perform as logic circuits, just like those bits of silicon in your PC. These tiny, DNA-based biological logic circuits determine how genes are interpreted (each gene may be interpreted in several ways), and, in the end, how lifeforms develop from embryo to adult. (Yuh, Chiou-Hwa, et al; "Genomic CisRegulatory Logic: Experimental and Computational Analysis of a Sea Urchin Gene," Science, 279:1896, 1998. Also: Wray, Gregory A.; "Promoter Logic, ...
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... Science Frontiers ONLINE No. 17: Fall 1981 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Why conserve junk?A. Jeffries, working at Leicester University with globin genes from man and related primates, has been studying how these genes direct the blood cells to make the alpha and beta chains of hemoglobin. Jeffries' analyses seem to indicate that the genes now coding for these hemoglobin chains are almost identical to those existing in human ancestors some 500 million years ago. Two curious facts have cropped up, however. First, about 200 million years ago, these genes were modified very slightly and relocated to entirely different chromosomes. Second, 95% of the DNA associated with these genes is "junk" -- with no known use. Why did nature conserve junk for 500 million years? Are vital genes in the habit of jumping from one chromosome to another? (Yanchinski, Stephanie; "DNA: Ignorant, Selfish and Junk," New Scientist, 91:154, 1981.) From Science Frontiers #17, Fall 1981 . 1981-2000 William R. Corliss ...
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... Science Frontiers ONLINE No. 136: JUL-AUG 2001 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Genome-map User Beware!Omissions. Amid much hullabaloo, it was announced recently that the human genome has now been mapped. To everyone's surprise, we are said to be constructed from blueprints containing only about 30,000 genes. But how accurate are these maps that were drawn up so hastily in the bitterly contested race between the publically and privately sponsored programs? How good are those computer programs that identified these 30,000 or so genes? According to W. Haseltine, who heads Human Genome Sciences, "They're reading smudged text through foggy glasses." Haseltine's company claims to have found more than 90,000 human genes. Two other organizations have identified between 60,000 and 65,000 genes. A research group at Ohio State University at Columbus analyzed the same data used by the public consortium and estimates that there are actually human 80,000 genes! In fact, this groups avers, the public consortium's software seems to have missed 850,000 gene segments for which there already exists protein or RNA evidence. The human genome map seems to harbor many terrae incognitae. So, we best not draw profound conclusions just yet. (Kintisch, Eli; "So What's the Score?" New Scientist, p. 16, May 12, 2001.) Errors. The genome-mapping efforts of both the public consortium and private company (Celera ...
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... Science Frontiers ONLINE No. 29: Sep-Oct 1993 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Genes aren't everything Many species of birds show considerable variation in size, shape, and coloration in various parts of their ranges. Hithertofore, such geographical variations had been considered to be genetically controlled; that is, the genes also varied with the geography. But experiments in which the eggs of redwinged blackbirds were interchanged between nests in northern and southern Florida and also between Colorado and Minnesota seem to show that the environment is more important than genetic endowment. In the redwinged blackbird, the bill size and shape and body weight of the transplanted birds (after hatching, of course) were characteristic of the locale in which they were raised rather than that where the eggs were laid. (James, Frances C.; "Environmental Component of Morphological Differentiation in Birds," Science, 221:184, 1983.) From Science Frontiers #29, SEP-OCT 1983 . 1983-2000 William R. Corliss ...
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... Science Frontiers ONLINE No. 16: Summer 1981 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Hooray, another "dangerous" book!The May 22, 1981, issue of Science devotes three entire pages to a discussion of the issues raised in the book Genes, Minds, and Culture, written by Edward Wilson and Charles Lumsden. The subject of this book is "gene-culture coevolution," which infers that human culture is controlled not so much by "free will" as by rapidly changing human genes. The authors propose that as few as 1000 years are sufficient for important genetic shifts. Such shifts might, for example, impel humans to break out of the Middle Ages and bring on the Industrial Revolution. The most controversial facets of the theory are: (1 ) The tight genetic control over human culture with little room for free will; and (2 ) The rapid blossoming of many cultures as genes shift about. As one scientist remarked, this book is "dangerous." Others describe it as marvelous. The Science article deals not so much with the book as with the reactions to it -- and the reactions have been powerful, both pro and con. (Lewin, Roger; "Cultural Diversity Tied to Genetic Differences," Science, 212:908, 1981.) Comment. The impression one gets from the synopsis of the book is that humankind is diversifying rapidly into new cultural configurations not through human volition but because of those imperious "selfish genes" we all carry. From Science ...
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... Science Frontiers ONLINE No. 134: MAR-APR 2001 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects What Sang First?Not WHO, but WHAT! Sophisticated music predates the advent of modern humans by tens or hundreds of million years. Whales and birds filled the ocean and primeval forest with song long before our hominid branch sprouted on the Tree of Life. As a matter of fact, our closest relatives, the great apes, sing not at all. Somewhere in the hominid genome "music" genes reside, unexpressed in the apes, but somehow triggered into activity in the human line. We have learned recently that the Neanderthals manufactured bone flutes as far back at 53,000 years. They may not have been able to speak to one another in words, but they had the language of music. Their music, and ours, may have been entrained in genes inherited from nonhominid ancestors that lived 60 million years ago, but which have been suppressed in primates until Neanderthals and modern humans came along. You may wonder where this argument is taking you. It goes back at least 60 million years to when the cetacea (whales and dolphins) split off from the evolutionary track leading to humans. It may even go back farther to when birds split away from the reptilian line. The music of birds and whales incorporate some of the complexity and sophistication of Beethoven's Fifth. The genes that have led to such musical talents may be ancient indeed, as speculated in the Science article under review. The authors go ...
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... words concerning this article that we never thought would be permitted in a mainstream science magazine. After first noting that 10 years ago it was generally agreed that all organisms evolved from a single ancestral cell that existed about 3.5 billion years ago, there comes the assertion that the Tree of Life: "is far more complicated than was believed and may not have had a single root at all." The article proper relates how the Tree of Life has its own evolutionary history. Twenty years ago, scientists had that single ancestral cell splitting into two main trunks: the prokaryotes (bacteria) and the eukaryotes (every-thing else). More recently, a third trunk has been grafted onto the Tree; namely, the archaea (microorganisms that look like bacteria but possess markedly different genes). The archaea favor extreme environments and, curiously, are more closely related to you and me than are the bacteria. But according to this article (by W.F . Doolittle), the triple-trunked Tree of Life is simplistic. One reason for this is that genes, once thought to flow only from parent to progeny, are now known to travel laterally. Species barriers are broken. Genes jump from trunk to trunk, from branch to branch, twig to twig. Of course, these jumps are seen primarily among the microorganisms. The real Tree of Life, then, is more like a snarl of vines--a Jungle of Life, a genetic Tower of Babel! Furthermore, no longer does the multiplicity of life forms spring from a single primordial ...
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... the paper of Robbins et al has been criticized because the earliest known fossils of metazoans date back to only about 1 Gyr and, therefore, the supposed pellets were obviously something else. Sager next makes a giant conceptual leap: Quite clearly the data prove that feces evolved before animals did!! He goes on: "In standard systematic reasoning, one assumes that the most widespread characteristic represents the primitive state. The fact that feces look so much the same from individual to individual strongly suggests that feces are the primitive condition. The variety of animal bodies, on the other hand, implies that bodies are secondary or derived features of the organisms. The expansion of genetic research in the twentieth century has led to the conclusion among many geneticists that bodies exist solely for the propagation and dispersal of genes. This perspective has been dubbed 'the selfish gene theory'. While the author acknowledges the insight and creativity that went into the selfish gene theory, it must be pointed out that the idea has not been carried far enough by the geneticists. Where did the genes come from in the first place? Who ever heard of a sea bottom made up of DNA ooze? It is obvious from the fossil data that feces were teeming in the Precambrian oceans well before DNA appeared on the face of the earth, and that feces were therefore the original driving force of life. Bodies exist for the propagation and dispersal of feces, and genes are simply the instructions used by feces in the manufacture of those bodies. This concept is best described as the 'selfish feces theory'." ...
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... Science Frontiers ONLINE No. 41: Sep-Oct 1985 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Scrapie Transmitted By Prions Scrapie is an infectious neurological disorder in sheep. The infectious agent has been isolated, but it consists only of geneless prions. Somehow, these prions, which are merely protein filaments, get into a sheep's brain and replicate themselves to cause scrapie. With no genetic material of their own, how do the prions multiply? Recent laboratory work suggests that the prions subvert a gene that normally dwells in the brain. With the help of this gene, an endless stream of prions emerges, and the animal is sick. In hamsters, which are employed in laboratory research on scrapie, a gene demarcated PrP has been implicated in scrapie. PrP is present in both healthy and infected hamster brains, but no one knows what its normal function is, if indeed it has one. (Anonymous; "Prion Gene," Scientific American, 253:60, July 1985.) Comment. One can make an immediate connection between the traitorous PrP genes in the hamster brains and the excess genetic material in humans and all life forms. Biologists commonly call excess genetic material "nonsense DNA" which only means that they haven't devined its purpose. But, as already sugested, these unused blueprints may have had some past purpose or will be called into action in the future. The purpose may be insidious, as in the case of scrapie, or vital to the organism's survival in some ...
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... Science Frontiers ONLINE No. 11: Summer 1980 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Hierarchies Of Evolution All organisms from man to mouse to amoeba are merely DNA's way of manufacturing still more DNA -- so goes the modern ramification of molecular biology and the Genetic Code. In other words, DNA and genes are selfish, and ultimate parasites, directing the evolution of life only to maximize the production of DNA. This theme is not the subject of this paper by Doolittle and Sapienza. Rather, they wonder about those nonsense DNA sequences that do not code for protein. The presence of these "useless" bits of genetic material is often explained in terms of gene "expression." Emphasis is always on maximizing the "fitness" of the organism (phenotype). Perhaps this seemingly excess genetic material actually maximizes the fitness (survivability) of the DNA itself. Evolution thus occurs at DNA and gene (genome) levels, despite what transpires at the organism (phenotype) level. (Doolittle, W. Ford, and Sapienza, Carmen; "Selfish Genes, the Phenotype Paradigm and Genome Evolution," Nature, 284:601, 1980.) Comment. We know that mitochondria and chloroplasts have their own genetic material; evolution may be occurring at this level, too, independent of pressures for change on the organisms. Waxing speculative, may there not be other hierarchies where systems are trying to maximize their own survivability, even at molecular, atomic, and subatomic levels? Don't laugh! ...
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... Sleep Cycle BHF33 Voluntary Suspended Animation BHF34 Human Mortality Correlated with Geomagnetic Activity BHF35 Nearly-Simultaneous Deaths of Twins BHF36 Curious Attitudes after Death Geophagy in Pregnancy and Health Evolution of Menopause Uncertain Purpose of REM Sleep Curious Nature of Anesthesia Evolution of Menstruation Fetal Growth Correlated with Solar Activity Evolution of Sex Purpose of Life after Menopause Decline in Sperm Counts Fetus Signals Timing of Birth How Embryo Development Is Controlled and Effected Cycles in Autistic Births Rhythms in Growth Evolution of Lactose Tolerance Twins and Occurrence of Nightmares Timing of the End of Sleep BHG HUMAN GENETICS BHG1 Human Chromosomes Less Evolved Than Ape Chromosomes BHG2 The Presence of Introns in Human Chromosomes BHG3 Human Chromosomes Lack the "Baboon Marker" BHG4 Y-Chromosome Analysis Suggests First Humans Were Pygmies BHG5 Human and Ape Chromosome Numbers Differ BHG6 Identical Twins May Have Different Genomes BHG7 Gene Imprinting: Parental Influence on Genes BHG8 The Accentuation of Inherited Traits in Succeeding Generations BHG9 Higher Variability of Mitochondrial DNA in Subsaharan Africans BHG10 Mitochondrial DNA Evolves Much Faster Than Nuclear DNA BHG11 Disparity between Human and Ape Phenotypes and Genotypes BHG12 Chimpanzee Mitochondrial DNA More Diverse Than That of Humans BHG13 Human Mitochondria Radically Different from Those of Other Organisms BHG14 Paternal Mitochondrial DNA can Be Inherited BHG15 African Nuclear DNA Is Distinct from That of Other Populations BHG16 Chromosome Banding Analysis Incompatible with DNA Analysis BHG17 Involucrin Analysis Conflicts with Mitochondrial DNA Analysis BHG18 Human Molecular Clocks Run More Slowly Than Those of Apes BHG19 Absence of Transitional Forms of Cytochrome C DNA Analysis and the Origin of Modern Populations High Deleterious Mutation Rates in Hominids Fetal DNA in Mother's Blood Epigenetic Inheritance Unique Human Lack of Retroviruses Neanderthal mtDNA Different Persistence of Cystic ...
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... ONLINE No. 130: JUL-AUG 2000 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects The Midi-Chlorians are with Us!Whoops! We meant to write "mitochondria" in that title. In the movie Star Wars, Episode 1: The Phantom Menace, Jedi master Qui-Gon Jinn explains the origin of the supernatural powers possessed by Jedi knights. It arises, he says, from microscopic lifeforms called chlorians" that dwell within all living cells and reveal the will of the Force. Mitochondria are popularly seen as mere powerhouses within cells, with little influence on the organisms they inhabit. They are, it is believed, just the distant progeny of bacteria that invaded complex cells hundreds of millions of years ago. With only 37 genes in their arsenal, human mitochondria would not seem to pose any threat to humanity. After all, we have about 100,000 genes per cell. Of course, mitochondria do evolve separately from us, and this is a bit disconcerting. Could they be more than mere symbionts? The midi-chlorians of the Jedi knights were "good guys", but our mitochondria sometimes seem to be working for an insidious alien Force. There is good evidence that they: Selected which of your mother's germ cells matured to produce you; Have decided your odds of living to be 100; and May influence your being afflicted with Parkinson's and Alzheimer's , as well as rarer disorders. The first item (or "force") is the most disturbing. Mitochondria ...
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... Science Frontiers ONLINE No. 41: Sep-Oct 1985 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Evolution's motor runs fast and quietly M. Kimura has been promulgating what he terms The Neutral Theory of Evolution. He concludes that "the most prev-alent evolutionary changes that have occurred at the molecular level, that is in the genetic material itself, since the origin of life on Earth are those that have been caused by random genetic drift rather than by positive Darwinian selection." Kimua maintains and can experimentally prove to some extent that the genetic material of all organisms changes rapidly and constantly. The genes change much more rapidly than scientists believed just a few years ago. We observe few if any changes at the phenotype level (organism morphology) because the overwhelming majority of these changes are neutral. They confer no significant advantage or disadvantage on the organism. In fact, Kimura and others have demonstrated that the fastest molecular evolution occurs in the least important genes. It is fastest of all in the pseudogenes or dead genes, which seem to have no discernable functions. In other words, the genetic engine is running, but the gears are in neutral! In Kimura's thinking, these molecular changes may eventually become important at the phenotype level if the environment changes or there is some other destabilizing influence. Kimura is the author of the 1983 book The Neutral Theory of Molecular Evolution. Although Kimura has some experimental support, his theory is not widely accepted. (Motoo Kimura; "The Neutral Theory of Molecular ...
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... Science Frontiers ONLINE No. 69: May-Jun 1990 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Don't pet your house plants!Researchers at Stanford's Medical Center were spraying Arabidopsis plants (in the mustard family) with hormones to see if they could trigger any of the plants genes. They could, and the treated plants grew up stunted. But, it was serendipitously discovered, the same genes could also be triggered by spraying with water, by gusts of wind, and even by the human touch. Evident-ly, some of the genes in these plants can be turned on by various environmental stimuli, and thus affect future plant development. This mechanism per-haps explains why trees along the seacoast and timberline are stunted. (Crawford, Mark H., ed.; "Nolo Me Tangere," Science, 247:1036, 1990.) Comment. One is tempted to ask how widespread this phenomenon is in biology. Are humans, for example, born with a console of gene-buttons that the environment can push - as in cancer? Or, even in evolution itself? From Science Frontiers #69, MAY-JUN 1990 . 1990-2000 William R. Corliss ...
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... Diffuse Individuals Epigenetic phenomena -- those phenomena beyond the pale of DNA -- are seen in "diffuse individuals" such as fungi, where it is difficult to separate individual units of life. To illustrate, some fungi may be 1,000 years old and extend for 35 acres (15 hectares) and yet possess a single, still unmodified genome. In his review of A. Rayner's new book Degrees of Freedom: Living in Dynamic Boundaries , T. Wakeford writes: "So, like the World Wide Web, a fungal network is decentralized. There is no central region capable of exerting control over the rest of the network. Rayner's own work suggests that the growth patterns of fungal filaments are forged as much by the environment that they encounter as by their genes. He believes that epigenetics, the process whereby opportunities in an organism's surroundings dictate which genes are expressed, is the norm in microorganisms. Genetic determinism is thus turned on its head." (Wakeford, Tom; "We Are the Fungus," New Scientist, p. 49, May 10, 1997.) Comment. Looking at the above situation from an information viewpoint, as one must these days, it seems that the environment can somehow "interpret" genes as the situation demands. In other words, genes are not "single-message" information carriers, but can be "read" in different ways according to the environment encountered by their "carriers"; that is, the organisms that bear them. Is this how "adaptive evolution" works ...
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... Science Frontiers ONLINE No. 92: Mar-Apr 1994 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Is immortality only a mutation away?Here follows the lead sentence of the abstract of a recent letter to Nature : "We have found that mutations in the gene daf-2 can cause fertile, active adult Caenorhabditis elegans hermaphrodites to live more than twice as long as wild type." (Kenyon, Cynthia, et al; "A C. elegans Mutant That Lives Twice as Long as Wild Type," Nature, 366:461, 1993.) Comment. C. elegans is a roundworm only about a millimeter long. Roughly a thousand cells make up its tiny body, and scientists have charted the birth and death of each cell from egg to adult. This roundworm's life is a mosaic of changing cells, as some die to make way for new cells with different agendas. Somehow this programmed sequence of cell death and birth can be slowed down by mutations and thus increase longevity. Wouldn't any mortal speculate that perhaps human longevity might, like that of C. elegans , be extended by modern gene manipulators? Sure, it's quite an extrapolation from roundworm to human, but our cells are programmed just like those of C. elegans . Change a gene here and there, and we might all live as long as Noah! From Science Frontiers #92, MAR-APR 1994 . 1994-2000 William R. Corliss ...
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... Science Frontiers ONLINE No. 23: Sep-Oct 1982 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Short-circuiting heredity Genes, those carriers of heredity, have turned out to be great gadabouts. Not only do they jump about within a species, but also between species, especially the simple prokaryotic organisms, such as bacteria. It is now well accepted that genes flow between different species of bacteria in physical contact, thus stirring the evolutionary pot. Until recently, scientists believed that the higher organisms, the eukaryotic species, including you and me, did not indulge in such "horizontal" traffic between species. But a few cases have now been found, one involving humans and a microorganism associated with tumors. And the search is just beginning, as biologists look for something they never thought of looking for before. (Lewin, Roger; "Can Genes Jump between Eukaryotic Species?" Science, 217:42, 1982.) Comment. This apparent short-circuiting of classical heredity channels supports the radical notion that evolutionary blueprints may be transmitted between divergent species. In the long view, may-be we should not malign viruses, germs, and biting insects! From Science Frontiers #23, SEP-OCT 1982 . 1982-2000 William R. Corliss ...
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... Science Frontiers ONLINE No. 25: Jan-Feb 1983 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Promiscuous Dna The cells of plants (photosynthetic eukaryotes) are genetically the most complex that biologists have discovered. Each cell has three genetic systems: its own, that of the chloroplasts; and that of the mitochondria. It is supposed that the chloroplasts and mitochondria were once free-living cells that linked up with the embryonic plant cell to form a symbiotic partnership, with the host "plant" cell being the dominant member. Up until now, the three genetic systems were thought to be discrete, each going down its own pathway. But chloroplasts genes have now been found inside plant mitochondria, overturning conventional wisdom. To sum it all up, DNA seems promiscuous -- no respecter of privacy and breaking down all isolating genetic barriers. This discovery at once raises a dozen questions. For example, are mitochondria genes in chloroplast cells? How far does this promiscuity go? Can the same thing happen in higher organisms; say, with humans and symbiotic microorganisms or even not-so-symbiotic disease organisms? Is there no stopping this DNA? (Ellis, John; "Promiscuous DNA -- Chloroplast Genes inside Plant Mitochondria," Nature, 299:678, 1982.) From Science Frontiers #25, JAN-FEB 1983 . 1983-2000 William R. Corliss ...
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... Science Frontiers ONLINE No. 63: May-Jun 1989 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects The Language Of Life Popular writers on biology are fond of saying that the genes and their DNA carry all information necessary for the development of an organism and the transfer of inherited characteristics. With the advent of the multibillion-dollar project to map the human genome (our genetic inventory), we have been seeing this extreme claim more often. The truth is that a map of the human genome will not tell us everything. By way of confirmation, we quote the lead paragraph from a recent article in New Scientist: "In the early days of molecular biology, during the 1950s and 1960s, scientists as much as journalists fuelled the euphoria that surrounded the cracking of the genetic code. The secret of life was revealed, so many people thought. As our understanding has grown, however, so has our awareness of our ignorance. Research at the forefront of the molecular sciences has shown that we can no longer regard DNA - the stuff of genes - as a direct and complete set of instructions for the synthesis of proteins. The evidence begins to suggest that messages in the DNA are, in themselves, no more precise than the symbols and sounds with which we communicate. As in the languages with which we are familiar, the correct sense of a message written in DNA seems to depend on the rigorous checking and correction of errors, and on the context in which they are read." The final sentence of the ...
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... Science Frontiers ONLINE No. 111: May-Jun 1997 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Chromosome Choreography Every biology student has seen sketches of the "dance of the chromosomes" that is performed when eukaryote (nucleuscontaining) cells divide. Because chromosomes are composed of genes and their DNA -- the information carriers of inheritance -- it reasonable to suppose that they are the "dance-masters." This expectation is enhanced if one holds that the genes are "selfish;" that is, they have their own evolutionary agendas, and all life forms exist only to execute their "will." But cell division would not occur at all without the action of the cell's bipolar spindle. This spindle is composed of microtubules -- rods of the protein "tubulin." Somehow , when cells are about to divide, they synthesize these microtubules, which then seem to organize themselves into orderly arrays (the bipolar spindles). Then, the microtubules sort out and separate the two sets of chromosomes required for the two new cells. So, far, our description conforms to what biologists have known and accepted for decades; but there is something more mysterious going on. In 1996, researchers discovered that they can actually substitute DNAcovered beads for the chromosomes, and the microtubules will still go through the motions of sorting and separating the chromosome-less strands. Actually, the microtubules will perform their act even without the DNA-covered beads. In a sense, the bipolar spindle is a puppetmaster, and the ...
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... Science Frontiers ONLINE No. 77: Sep-Oct 1991 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Do birds use genetic maps during migration?Routes taken by migrating German and Austrian blackcaps en route to Africa. Hybrids bisect these initial paths and would end up in the Alps. Many young birds migrate successfully without help from older birds who have made the trip before. The implication is that migration instructions, perhaps even some sort of map of astronomical or geo graphical references, are somehow written upon the genes inherited from their parents. Just how maps can be coded into gene structure is anyone's guess. (In fact, since the DNA in the genes seems to cody only for protein synthesis, the locations and characters of inheritable maps and other biological instructions are not immediately obvious.) The problem has been exacerbated by recent experiments with German and Austrian blackcaps. These two common European warbler species take different routes to Africa in the winter. The Ger-man blackcaps fly southwest and the Austrian southeast--routes 50 apart. A. Helbig has crossed the German and Austrian blackcaps to see what route(s ) their hybrid offspring would take. Curiously, they favored a route intermediate between those of their parents. The hybrids' route -- bisecting those of the parents' -- would take the hybrids right into the Alps, where survival would be unlikely. (Day, Stephen; "Migrating Birds Use Genetic Maps to Navigate," New Scientist, p. 21, April 21, 1991.) ...
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... Science Frontiers ONLINE No. 22: Jul-Aug 1982 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects The Nomads Within Us It was originally believed that human chromosomes were fixed at conception and all subsequent organic development proceeded from the instructions encoded on them. Biologists have recently discovered that genes grasshopper about, constantly modifying genetic instructions -- at least that's the current thinking. Additional modification of genetic instructions seems to be accomplished by entities called "nomads" or "mobile dispersed genetic elements." One type of nomad is a simple ring of DNA called a plasmid. Plasmids seem to be identical to a kind of virus called a retrovirus, which can penetrate into cells and tamper with gene expression; that is, the way genetic instructions are interpreted. Plasmids have been discovered in maize, fruit flies, bacteria, and, now, humans -- and healthy people at that. No one is quite sure what these plasmids do. Even though they look like retroviruses, they may not be associated with illness, but rather help organisms adapt to changing environments. But no one really knows. (Anonymous; "Human Wandering Genes Can Live on Their Own," New Scientist, 94:18, 1982.) Comment. So, the human body is not only beset by new genetic instructions and the static introduced by invading viruses and other disease agents, but it has an indigenous population of nomads continually fiddling with our cells' genetic instructions. Our bodies seem more like Grand Central Station with trains loaded with new biological ...
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... Science Frontiers ONLINE No. 139: Jan-Feb 2002 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects The Second Genetic Code And Apparently A Third Genes may or may not be switched on depending upon the addition of molecules called "methyl groups" to DNA. Now, a second kind of gene switch has been discovered on histones, a class of proteins. Figuring out when methylation of histones takes place has far-reaching implications; acting as a second genetic code, histone methylation may determine genetic traits such as the susceptibility to disease. (Martindale, Diane; "Genes Are Not Enough," Scientific American, 285:22, October 2001.) Comment. So, beyond the first genetic code (the DNA) and the second genetic code (the recognized methyl groups), we now have some proteins (the histones) getting in on the act. And the show ain't over yet! From Science Frontiers #139, Jan-Feb 2002 . 2001 William R. Corliss Other Sites of Interest SIS . Catastrophism, archaeoastronomy, ancient history, mythology and astronomy. Lobster . The journal of intelligence and political conspiracy (CIA, FBI, JFK, MI5, NSA, etc) Homeworking.com . Free resource for people thinking about working at home. ABC dating and personals . For people looking for relationships. Place your ad free. ...
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... Science Frontiers ONLINE No. 41: Sep-Oct 1985 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Genetic Garrulousness It is tempting to predict that those cells with the most genetic material will belong to the most advanced organisms. One would, for example, expect to find more DNA or nucleotide pairs in human cells than the cells of bacteria or plants. In the case of the bacteria, this expectation is realized. Some plants, however, have one hundred times more DNA per cell than humans. Some fish and salamanders do, too. One reason why there is no simple relationship between a cell's genetic complement and the organism's complexity is that a lot of genetic material is apparently useless, with no known functions. Human genes, by way of illustration, possess about 300,000 copies of a short sequence called Alu. The Alu sequences seem to be simply dead weight -- functionless -- yet continuously reproduced along with useful sequences. One purposeless mouse gene sequence is repeated a million times in each cell. (Stebbins, G. Ledyard, and Ayala, Francisco J.; "The Evolution of Darwinism," Scientific American, 253:72, July 1985.) Comment. Why so much redundance? Or is there some purpose for this excess genetic material that we haven't yet descried? The "useless" sequences may merely be left over from ancient gene shufflings; or they may be awaiting future calls to action. The above tidbits come from a long review article that is generally ...
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... Science Frontiers ONLINE No. 34: Jul-Aug 1984 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects A Note On Perfect Pitch An individual with perfect pitch can identify a tone without hearing a second tone for comparison. It is difficult to avoid the conclusion that such individuals possess a set of frequency standards somewhere in their permanent memories. The less fortunate of us do not have the genes that lead to the construction of these cerebral frequency standards. (Anonymous; "A Note on Perfect Pitch," Scientific American, 250:82, June 1984.) Comment. Question 1. Does perfect pitch have any survival value that would stimulate its evolution? Question 2. How are these frequency standards coded on the genes? From Science Frontiers #34, JUL-AUG 1984 . 1984-2000 William R. Corliss ...
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... ." Although These People Did Mummify Their Dead -- like Several Other Ancient Cultures -- they Were Far From Being Cadavers When They Drove The Russians Off The Beach Of Kodiak Island With A Rain Of Sharp Darts, Spears, And Lances. According To A Recent Article In Ancient American, They Also Launched Large Stones At The Russians Using Catapults! Protected By Body Shields Made Of Wood Covered With Rawhide, The Mummy People -- what Was Left Of Them -- were Formidable Warriors. But Who Were They? Actually, The Russians Were Not The First To Meet The Mummy People In Mortal Combat. The Eskimos Had Faced Them In Their Island-by-island Conquest Of The Aleutians Begun Several Centuries Earlier. Today'S Aleuts Carry A Mixture Of Eskimo And Mummy-people Genes. It Is The Uncertain Origin Of The Mummy People That Intrigues The Most. They Are Thought To Have Arrived In The Aleutians Some 7,000 Years Ago -- but From Where? Helping To Answer This Question Are Thousands Of Their Mummies Unearthed Over The Last 300 Years. Their Bones Resemble Those Of The Ainus Still Surviving In Northern Japan. Like The Ainus, The Mummy People Possessed Some Caucasian Features. In Fact, Some Had Reddish Hair. The Ancient American Article Adds That The Ancient Aleuts Used The Decimal System, Manufactured White Parchment, And Made Fires Using Combustible Sulphur And Sparks Struck From Pyrite. (Pettyjohn, F.s .; "Who Were The Caucasian 'Mummy People' Of Alaska?" Ancient American, No. 39, P. 26, 2001 ...
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... Science Frontiers ONLINE No. 64: Jul-Aug 1989 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Directed Mutation Dear reader, things have a way of working out serially. For several months, we have had in our possession a paper from Nature, by J. Cairns, of Harvard, plus some passionate correspondence stimulated by the paper. Now that the circle-forming sheep have provided a good introduction, we will jump into the fray, too. Basically Cairns (in Nature) and B. H. Hall (in Genetics ) say that organisms can respond to environmental stresses by reorganizing their genes in a purposeful way. Such "directed mutation" shifts the course of evolution in a nonrandom way. Such a conclusion was like waving a red flag in front of the evolutionists. R. May, at the University of Oxford, complained, "The work is so flawed, I am reluctant to comment." On the other side, a University of Maryland geneticust, S. Benson, comments, "Many people have had such observations, but they have problems getting them published." Our template in this discussion is an article by A.S . Moffat in American Scientist. She says, "The stakes in this dispute are high, indeed. If directed mutations are real, the explanations of evolutionary biology that depend on random events must be thrown out. This would have broad implications. For example, directed mutation would shatter the belief that organisms are related to some ancestor if they share traits. ...
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... Science Frontiers ONLINE No. 129: MAY-JUN 2000 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects A Third Way?A THIRD WAY? In the never-ending, ever-acrimonious "dialog of the deaf" between the Darwinists and the Creationists, we are perpetually exposed to their extreme, non-negotiable positions. The Darwinists insist upon their one-gene/one-protein genome in which random mutations slowly accumulate and adapt living things to the changing environment. The Creationists only accept a one-time, supernatural creation of "kinds" plus minor adaptations (" microevolution"). J.A . Shapiro, a professor at the University of Chicago, is searching for a "third way," a scientific, non-Darwinian way. Shapiro maintains that five decades of genetic and molecular-biology research have transformed our vision of life. Ile compares the conceptual changes to those accompanying the transition from classical physics to relativity and quantum mechanics. This new theory of evolution -- his "third" way -- will emerge from the convergence of biology and information science. Genomes, asserts Shapiro, are not really the static "beads on a string" envisioned by the Darwinians. Rather, they are fluid and complex. Genes are now seen as multipurpose elements that turn on and off as required for the survival and well-being of the organism they belong to. In this paradigm-eroding paper (referenced below), Shapiro describes four categories of molecular discoveries that have revised our thinking about how ...
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... ONLINE No. 2: January 1978 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Hopeful monsters rather than gradual evolution?S. J. Gould, who conducts a monthly column in Natural History reviews the sad history of Goldschmidt and his villification by the scientific establishment. Goldschmidt saw the fossil record as woefully inadequate to justify the assumption of gradual evolution of one form into another. Intermediate forms between separate species do not seem to exist in the fossil record and, if they did, they would probably not have been viable creatures. What good is half a wing? Gould believes that Goldschmidt's "hopeful monster" concept will ultimately be dusted off. The key to "macromutation," Gould feels, is not to be found in major gene reorganizations that might produce a whole wing, feathers included, all at once, but rather in changes in the genes that control the development of embryos. Embryos in their early stages are pretty much alike regardless of species. Gould hopes further that the ruling neo-Darwinians will not be so hostile to new ideas and eventually acknowledge Goldschmidt's important work. (Gould, Stephen J; "The Return of the Hopeful Monster," Natural History, 86: 22, June-July, 1977.) From Science Frontiers #2 , January 1978 . 1978-2000 William R. Corliss ...
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... subject of two SF items (SF#60/187 and SF#85/ 187). A paleontological fact of life is that all known body plans (phyla) seem to have evolved suddenly -- within a few million years -- after the onset of the Cambrian period some 545 million years ago. Evolutionists are understandably uncomfortable with such a high rate of evolutionary innovation. Nothing like the Cambrian Explosion appears in the hundreds of millions of years of geological strata that followed. So rapid was speciation during the Cambrian Explosion that doubt is cast upon the accepted mechanisms of evolution: slow, stepwise accumulation of mutations plus natural selection. (Refs. 1 and 2) But G.A . Wray and colleagues seem to have rescued Darwinism. They have analyzed the DNA sequences of seven genes found in living animals. Assuming that these genes mutate at constant rates and working backwards in time, they calculate that animal diversification (i .e ., when chordates diverged from invertebrates) actually began about 1 billion years ago, rather than about 545 million years ago. This expansion of the time frame gives accepted evolutionary processes much more time to innovate and create all those new body plans. The evolutionists are pleased. The paleontologists, however, are in a quandry. They see nothing -- or very little -- in the Precambrian fossil record that substantiates the claim of Wray at al. Thus, molecular biology directly contradicts the findings of paleontology. Not to worry say supporters of the new and much more comfortable scenario: The Precambrian animals were so soft and "squishy" ...
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... use of language, the method of locomotion, and of course culture. Less well known is the fact that humans are more susceptible to diseases like as cancer and AIDS. Apparently, superficial comparisons of DNAs slough over genetic details that result in major differences in the living animals. Some of the genetic differences between humans and chimps seem to belie that miniscule 1.5 % difference everyone bandies about. To illustrate, humans have only 46 chromosomes, while the great apes all have 48. The 1.5 % figure doesn't hint at this significant difference. Next, take a look at chromosome #9 in humans and the great apes. Chromosome bandings are different enough to raise further suspicions about the 1.5 % figure. (Gibbons, Ann; "Which of Our Genes Make Us Human?" Science, 281:1432, 1998.) Comments. It is easy to see how gross comparisons of DNA might miss important details. The popular "DNA-hybridization" method simply mixes together strands of DNA from the two species being compared. These are allowed to combine, and then they are heated to see how much temperature is required to force them apart. Chromosome numbers and bandings have little if any effect on these crude comparisons of the bare DNA strands that have been stripped from their genes and chromosomes. The significance of all this transcends the comparisons of humans and chimps. Modern taxonomy of all life forms depends increasingly upon DNA comparisons rather than upon morphology. If DNA comparisons can be as misleading as they are in humans and chimps, those textbook ...
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... (in case you wondered) defines "eusociality": "The weevil Austroplatypus incompertus lives in galleries in the heartwood of Eucalyptus trees. Colonies are initiated by solitary fertilized females and, when mature, manifest the three phenomena which characterize eusociality: overlapping generations, cooperative brood care and division into reproductive and sterile (unfertilized) castes. Each colony contains one fertilized and five or so unfertilized adult females, the job of the second group being to deal with predators and to extend and maintain the galleries." (Anonymous; "Sociable Beetles," Nature, 356:111, 1992.) Comment. Eusociality is somewhat of a puzzle in evolutionary theory because one must ask how the phenomenon arises, when it requires some individuals to forswear reproduction and thus give up the chance to pass their genes directly on to progeny. Explanations of such extreme altruism generally state that the nonbreeders are really helping to pass some (or even all) of their genes on by supporting the colony, for they are usually closely related to the breeding female. From Science Frontiers #81, MAY-JUN 1992 . 1992-2000 William R. Corliss ...
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... (cells with nuclei). Humans and most of the life forms we are familiar with belong to the latter group. (Curiously, human red blood cells lack nuclei!) However, a third basic type of life has been found prospering in some extreme environments. These are the Archea, typified by the methane-producing microbes discovered clustered around hot deepsea vents, where temperatures may exceed 400 C. It is not their rugged constitutions that place these miniscule forms of life in a new category; it is their genomes. They are radically different from those found in prokaryotes and eukaryotes. The genome of one species of Archea collected from a hot vent 3 kilometers deep in the Pacific has been sequenced. Biologists were taken aback. Methanococcus jannaschii , as it has been dubbed, possesses 1738 genes, of which 56% are entirely new to science. Many of these genes do not look anything like those found in the prokaryotes and eukaryotes. In a word, they seem "alien." (Morell, Virginia; "Life's Last Domain," Science, 273:1043, 1996.) How alien? Well, they are so tough that they could have arrived from Mars on a meteorite. Millions of years of residence in a meteorite edging its way toward a rendezvous with earth mean nothing to the Archea. They have even been cultured from the interior of a salt crystal 200 million years old. (Fanale, Fraser; "Martian Substances," Science, 275:321, 1997.) From Science Frontiers #112, JUL-AUG 1997 . ...
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... planktonic microorganisms, and that viruses might mediate genetic exchange among bacteria in natural aquatic environments." (Bergh, Oivind, et al; "High Abundance of Viruses Found in Aquatic Environments," Nature, 340:467, 1989.) A sip of water could therefore introduce a billion virus particles into your stomach! This level of virus density in natural water is about 10 million times that formerly estimated. Besides reducing your thirst, what are the implications of this discovery? First, it suggests that bacteria in natural waters are probably kept in check by viruses as well as protozoans. So far, this sounds good. Second, since viruses can ferry genetic material between organisms via transduction (i .e ., host DNA is carried to the next host). This means that genes for antibody resistance and increased bacterial virulence (as present in sewage) may be spread quickly and widely. Also, "engineered bacteria" proposed for use in agriculture, viz., the ice-minus bacterium created to protect strawberries, may die, but their new genes will soon be everywhere. (Weiss, R.; "Aquatic Viruses Unexpectedly Abundant," Science News, 136: 100, 1989.) From Science Frontiers #66, NOV-DEC 1989 . 1989-2000 William R. Corliss ...
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... with an inwardly directed arrow carrying life-forms (Hoyle's space viruses and bacteria), meteorites, icy comets, etc. Likewise, the earth can contribute life-forms to the cosmos via impact and volcanic ejecta. Where does geocorrosion fit in? Life-as-a -whole could control terrestrial magnetic field reversals geochemically. This sounds more and more like science fiction, but life-as-a -whole must "want" to evolve to make itself more adaptable and capable of controlling and exploring the cosmos. (These are anthropomorphic desires we assign to life-as-awhole, which may have completely different objectives!) By occasionally reducing the earth's field to zero, bursts of space radiation would be admitted to stir the earth's pot of genes. We could also work in "selfish genes" and God, but it is time to go back to anomalies once more. From Science Frontiers #48, NOV-DEC 1986 . 1986-2000 William R. Corliss ...
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... Science Frontiers ONLINE No. 25: Jan-Feb 1983 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Why don't we all have cancer?Biologists have just found that the difference between a normal human gene responsible for manufacturing a specific protein and a gene causing cancer is the replacement of a single nucleotide by another in a very long string of nucleotides. This is a very delicate situation. The difference between cancer and no cancer is simply too tiny. Given the high frequency of random changes (mutations), we should all have cancer. One implication is that humans (and other animals, too) have come up with some method of preventing or correcting these minor mutations -- otherwise we would have become extinct long ago. No one knows what this mechanism is or why it sometimes fails. (Anonymous; "More Speculation about Oncogenes," Nature, 300;213, 1982.) Reference. Other anomalies of cancer are cataloged in BHH23-35 in: Biological Anomalies: Humans II. For a description of this volume, visit: here . From Science Frontiers #25, JAN-FEB 1983 . 1983-2000 William R. Corliss ...
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... Science Frontiers ONLINE No. 115: Jan-Feb 1998 Issue Contents Other pages Home Page Science Frontiers Online All Issues This Issue Sourcebook Project Sourcebook Subjects Evolvable Hardware First, you must envision a computer chip as an evolvable entity -- an array of logic gates that can be connected in an almost infinite number of ways. A soft-ware instruction becomes the equivalent of a biological gene. Software instructions can be changed to achieve certain hardware goals just as genes can be rearranged to modify an organism. Furthermore, human operators can specify a hardware goal to the chip and let it evolve on its own, something it can do in microseconds rather than millions of years. This is not a frivilous subject. D. Fogel, chief scientist at Natural Selection, Inc., in La Jolla, California, asserts: "Eventually, we will need to know how to design hardware when we have no idea how to do it." A few demonstration devices have already been built, and in them we see something worthy of note for Science Frontiers. One such device, built by A. Thompson, University of Sussex, was tasked to identify specific audio notes by certain voltage signals. Given 100 logic gates, the device needed only 32 to achieve the result. The surprise was that some of these working gates were not even connected to others by normal wiring. Thompson admitted that he had no idea how the device worked. Something completely unexpected had evolved. Perhaps, thought Thompson, some of the circuits are coupled electromagnetically rather than by wires. Human engineers would never ...
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... were ever going to undergo significant degrees of evolution from parent stock and obtain resultant speciation, surely the Kaibab squirrel would be one of the more likely candidates. Supposedly isolated from their neighbors for hundreds of thousands of generations over a period of at least several million years, and significantly violating virtually every restriction of the Hardy-Weinberg equilibrium for the non-evolving population, these organisms, even by creationist standards, should have undergone significant and detectable changes. In reality all they show are moderate changes, primarily in two coat color characteristics for part of their population. To make things even worse, this species is known to have a highly variable coat-color polymorphism throughout its range. Thus, even the differences displayed appear to be easily accounted for by several mutations and a slight change in gene frequency for one or two loci, all occurring in a limited period of time. "If an organism such as the Kaibab squirrel is able to escape all but a few minor changes in coat color (and these of dubious survival value) given the supposed immense time of rather complete isolation and violation of the Hardy-Weinberg equilibrium, we must ask wherein lies the fault. Is it in the violation of the Hardy-Weinberg concept, or is it in the time alloted for gene pool changes to occur?" Meyer answers his questions by stating that the Hardy-Weinberg equilibrium concept seems reasonably well-founded, so that the problem must lie in the length of time estimated for the Kaibab squirrel's isolation from surrounding populations. In effect, Meyer concludes that the Grand ...
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